Healthful supplement food

ABSTRACT

Supplemental food formulations are described herein that can contain various nutrients, including at least four of the following: amino acid blend, fulvic-humic acids, multi-minerals, glycerin, phosphatidylinositol, sesquiterpene alkaloids, terpenes, medium-chain triglycerides (MCTs), coconut oil, whole plant matter, plant seeds, mushrooms, seaweeds, kelp, and flavoring agents.

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of priority to U.S. ProvisionalPatent Application Ser. No. 62/464,987 entitled “Healthful SupplementFood,” filed Feb. 28, 2017, the complete disclosure of which isincorporated herein by reference in its entirety.

BACKGROUND

Many nutritional supplements and ‘superfoods’ are currently available.However, most currently available nutritional supplements fail toprovide optimal health benefits. Moreover, currently availablenutritional supplements are often developed for mass marketing andconsumption. As a result, these nutritional supplements are manufacturedto maximize convenience for the manufacturer and quality is oftensacrificed. Mass produced nutritional supplements often includeundesirable ingredients such as preservatives, chemicals and heavymetals rather than clean, safe and non-toxic ingredients.

SUMMARY

Clean, safe, and non-toxic dietary nutritional supplement food thatprovide optimal health benefits are described herein. Dietarynutritional supplement foods, such as those described herein, arebelieved to be particularly useful as health supplements.

The supplement foods described herein have no negative side effects andcan optimize health of animals, including humans, who receive them. Thesupplemental food contains a number of nutrients including at least fourof the following: amino acid blend, Fulvic-humic acids, multi-minerals,glycerin, phosphatidylinositol, sesquiterpene alkaloids, terpenes,medium-chain triglycerides (MCTs), coconut oil, whole plant matter,plant seeds, mushrooms, seaweeds, kelp, and flavoring agents. In somecases, the supplement food(s) can include one or more freshnesspreservation compound(s). The supplement food formulation can be in theform of a powder, liquid, suspension, gel, health bar (e.g. chewy,crispy, or soft), or other form of food.

DETAILED DESCRIPTION

The supplement food can include at least four of the followingcomponents: amino acid blend, Fulvic-humic acids, multi-minerals,glycerin, phosphatidylinositol, sesquiterpene alkaloids, terpenes,medium-chain triglycerides (MCTs), coconut oil, whole plant matter,plant seeds, mushrooms, seaweeds, kelp, and flavoring agents. In somecases, the supplement food can include at least five, or at least ofsix, or at least seven, or at least eight, or at least nine, or at leastten, or at least eleven, or at least twelve, or all of the foregoinglisted components. The supplement food(s) can also optionally includeone or more freshness preservation compound(s).

The supplement foods have surprising benefits, such as reducing theincidence and/or severity of disease relative to an animal (or human)who does not receive the supplements. Humans and animals that receivethe supplements can exhibit resistance to disease and improved immuneresponses. Humans and animals that receive the supplements can havereduced pain, disease improvement, more energy, improved sleep patterns,increased activity levels, reduced extremity numbness, improveddigestion, fewer headaches, reduced symptoms, fewer tumors, fewer cancercells, and/or fewer seizures, compared to their own experience prior totaking the supplements.

The supplement foods can be administered to animals, including humans,domesticated animals (e.g., dogs, cats, horses, cattle, pigs, goats,poultry, sheep, alpacas, llamas, and the like), zoo animals,experimental animals (e.g., mice, rats, guinea pigs and the like), andwild animals.

Amino Acid Blend

The amino acid blend can include any of the genetically encoded aminoacids, as well as non-genetically encoded amino acids. Examples of aminoacids that can be included in the supplement food formulations are asshown in Table 1.

TABLE 1 One-Letter Common Amino Acid Symbol Abbreviation Alanine A AlaArginine R Arg Asparagine N Asn Aspartic acid D Asp Cysteine C CysGlutamine Q Gln Glutamic acid E Glu Glycine G Gly Histidine H HisIsoleucine I Ile Leucine L Leu Lysine K Lys Methionine M MetPhenylalanine F Phe Proline P Pro Serine S Ser Threonine T ThrTryptophan W Trp Tyrosine Y Tyr Valine V Val β-Alanine bAla2,3-Diaminopropionic acid Dpr α-Aminoisobutyric acid Aib N-Methylglycine(sarcosine) MeGly Ornithine Orn Citrulline Cit t-Butylalanine t-BuAt-Butylglycine t-BuG N-methylisoleucine Melle Phenylglycine PhgCyclohexylalanine Cha Norleucine Nle Naphthylalanine Nal Pyridylalanine3-Benzothienyl alanine 4-Chlorophenylalanine Phe(4-Cl)2-Fluorophenylalanine Phe(2-F) 3-Fluorophenylalanine Phe(3-F)4-Fluorophenylalanine Phe(4-F) Penicillamine Pen 1,2,3,4-Tetrahydro- Ticisoquinoline-3-carboxylic acid

 -2-thienylalanine Thi Methionine sulfoxide MSO Homoarginine hArgN-acetyl lysine AcLys 2,4-Diamino butyric acid Dbu

 -Aminophenylalanine Phe(pNH₂) N-methylvaline MeVal Homocysteine hCysHomoserine hSer Amino hexanoic acid Aha Amino valeric acid Ava2,3-Diaminobutyric acid Dab

In some cases, the amino acid blend includes genetically encoded aminoacids such as at least five, or at least six, or at least seven, or atleast eight, or at least nine, or at least ten, or at least eleven, orat least twelve, or at least thirteen, or at least fourteen, or at leastfifteen, or at least sixteen, or at least seventeen, or at leasteighteen, of the following: alanine, arginine, aspartic acid, cysteine,cystine, glutamic acid, glycine, histidine, isoleucine, lysine, leucine,methionine, phenylalanine, serine, proline, threonine, tryptophan,tyrosine, and/or valine.

For a single serving, the amount of each component of the amino acidblend can range from about 1 μg/Kg to about 15 mg/Kg, or from about 0.5mg/Kg to about 12 mg/Kg, or from about 1 mg/Kg to about 10 mg/Kg of theanimal, or any intervening amount thereof.

Fulvic Acid/Humic Acid

The supplement foods described herein can include fulvic and/or humicacids. Humic acid is a component of humic substances, which are themajor organic constituents of soil (humus), peat, and coal; humus canalso be found in some upland streams, dystrophic lakes, and ocean water.Humic acid is produced by biodegradation of dead organic matter. It isnot a single acid. Instead, it is a complex mixture of many differentacids containing carboxyl and phenolate groups so that the mixturebehaves functionally as a dibasic acid or, occasionally, as a tribasicacid. Humic acids can form complexes with ions that are commonly foundin the environment creating humic colloids. Fulvic acids are humic acidsof lower molecular weight and higher oxygen content than other humicacids.

Humic substances in soils and sediments can be divided into three mainfractions: humic acids, fulvic acids, and humin. The humic and fulvicacids can be extracted as a colloidal sol from soil and other solidphase sources using basic aqueous solutions of sodium hydroxide orpotassium hydroxide. Humin is insoluble in dilute alkali and istherefore not collected by basic extraction. Humic acids areprecipitated from basic solutions by adjusting the pH to 1 withhydrochloric acid, leaving the fulvic acids in solution. This solubilitydifference at acidic pH is the operational distinction between humic andfulvic acids.

Humic and fulvic acids are commonly used as a soil supplement inagriculture, and less commonly as a human nutritional supplement. As anutrition supplement, fulvic acid can be found in a liquid form as acomponent of mineral colloids. Fulvic acids are poly-electrolytes andare unique colloids that diffuse easily through membranes whereas allother colloids do not.

Humic and fulvic acids can react with the chemicals used in thechlorination process, which is sometimes used for generating drinkingwater, to form disinfection byproducts such as dihaloacetonitriles,which are toxic to humans. Although water is generally not used forpreparing humic and fulvic acids or the supplements described herein, ifwater is used to prepare or formulate humic and fulvic acids, a puresource of water (without chlorine or chlorination byproducts) is used.

Humic and fulvic acids are available commercially and can be obtained,for example, from SupremeFulvic (see website at SupremeFulvic.com). Aconvenient source of the fulvic-humic acids and the minerals used in thesupplements described herein is Vital Earth—Fulvic Mineral Complex IonicMineral Supplement (see, e.g., website atvitacost.com/vital-earth-minerals-fulvic-mineral-complex?csrc=GPF-PA-Vitamins%20%26%20Supplements-855748000016&ci_gpa=pla&ci_kw=&ci_src=17588969&ci_sku=855748000016&CGlid=CM6DquuutcYCFdgLgQodpKOMFQ).

The amount of humic/fulvic acids that are present in a single serving ofthe supplement food can range from about 1 mg/Kg to about 50 mg/Kg, orfrom about 5 mg/Kg to about 40 mg/Kg, or from about 10 mg/Kg to about 30mg/Kg of the animal, or any intervening amount thereof. In some cases, aserving of the humic/fulvic acid content can be about 20 mg/Kg of theanimal. For example, one serving of Vital Earth—Fulvic Mineral ComplexIonic Mineral Supplement can be about 0.5 to about 2 fluid ounces. Thehumic/fulvic acids can be an optional ingredient.

Multi-Minerals

The supplement foods described herein can include small amounts ofminerals or salts thereof. Examples of such minerals can includeantimony, barium, beryllium, bismuth, boron, bromine, cadmium, calcium,cerium, cesium, chloride, chromium, cobalt, copper, dysprosium, erbium,europium, fluorine, gadolinium, gallium, germanium, gold, hafnium,holmium, indium, iodine, iridium, iron, lanthanum, lithium, lutetium,magnesium, manganese, molybdenum, neodymium, nickel, niobium, osmium,palladium, phosphorous, platinum, potassium, praseodymium, rhenium,rhodium, rubidium, ruthenium, samarium, scandium, selenium, silicon,silver, sodium, strontium, sulfur, tantalum, tellurium, terbium,thulium, thorium, tin, titanium, tungsten, vanadium, ytterbium, yttrium,zinc, zirconium, or any combination thereof.

The minerals of the listed elements can be used as salts. For example,the listed elements can be employed as their customary cations and/oranions in combination with corresponding gegenions. For cations, thehalogen, sulfate, nitrate, and phosphate salts are typically employed.For anions such as oxygenated forms of transition metals andnon-metallic elements (Groups III-VII of the Periodic Chart), alkalineand alkaline earth metal salts are typically employed.

The amounts of minerals in the supplement food can vary. For example,the minerals in a single serving of the supplement food can range fromabout 0.01 μg/Kg to about 100 mg/Kg, or from about 0.1 μg/Kg to about 50μm/Kg, or from about 1 μg/Kg to about 40 mg/Kg, or from about 1 mg/Kg toabout 40 μg/Kg, or from about 2 mg/Kg to about 30 μg/Kg, or from about 5mg/Kg to about 30 μg/Kg of the animal, or any intervening amountthereof.

Glycerin

The supplement foods described herein can include glycerin. In somecases, the glycerin can be a vegetable glycerin, or glycerol. Glycerinor glycerol is a clear, odorless liquid typically produced from plantoils. For example, the vegetable glycerin can be obtained from palm oil,soy oil, coconut oil, or a combination thereof. It has a flash point ofapproximately 177° C., and a boiling point of 290° C. (554° F.).Accordingly, it can be subjected to processing at room temperature andat the temperatures described herein for manufacturing the supplementalfood. Vegetable glycerin is relatively nontoxic. The MSDS indicates thatthe LD₅₀ oral rat dosage is 12,600 milligrams per kilogram of bodyweight, which is approximately 5.7 grams per pound of body weight, or 36ounces for a 180 pound male. By comparison, acute oral toxicity (LD₅₀)in rats for sucrose (table sugar) is 29700 mg/kg and the acute oraltoxicity (LD₅₀) in rats for ethyl (grain) alcohol is about 7060 mg/kg.

Vegetable glycerin can be obtained from a variety of sources such asfrom Bulk Apothecary (see website atbulkapothecary.com/raw-ingredients/other-ingredients-and-chemicals/glycerin/?gclid=Clabgs_2pcYCFUI8gQodcmYNHw)or from Sigma-Aldrich (see website atsigmaaldrich.com/catalog/search?term=Glycerine&interface=All&N=0&mode=partialmax&lang=en&region=US &focus=product).

The amount of glycerin that are present in a single serving of thesupplement food can range, for example, from about 0.1 mg/Kg to about100 mg/Kg, or from about 1 mg/Kg to about 80 mg/Kg, or from about 2mg/Kg to about 60 mg/Kg of the animal, or any intervening amountthereof. In some cases, the glycerin content can be about 45 mg/Kg perserving.

Phosphatidylinositol

The supplement foods described herein can include one or more types ofphosphatidylinositol. Phosphatidylinositol is a family of lipids thatinclude a phosphoinositol sugar. The phosphate can be on the 3-position,the 4-position, or the 5-position of the inositol. In some cases, theinositol can have two phosphate residues on the 3-position, the4-position, and/or the 5-position. Phosphatidylinositol can be obtainedfrom Sigma-Aldrich.

The amount of phosphatidylinositol that are present in a single servingof the supplement food can range, for example, from about 0.1 mg/Kg toabout 10 mg/Kg, or from about 0.2 mg/Kg to about 5 mg/Kg, or from about0.3 mg/Kg to about 2 mg/Kg of the animal, or any intervening amounttherein.

Terpenes/Sesquiterpene Alkaloids

The supplement foods described herein can include one or more terpenes,as well as one or more sesquiterpene alkaloid compounds. For example,the supplement foods described herein can include a variety of terpenessuch as alpha-humulene, alpha-phellandrene, alpha-pinene,alpha-terpinene, alpha-terpinolene, beta-myrcene, beta-pinene, camphene,cis-ocimene, delta-3 carene, limonene, or combinations thereof.

Sesquiterpene alkaloid compounds include sesquiterpenes that have abasic nitrogen. One example is huperzine A, with the followingstructure.

Huperzine A (“huperzine”) is an alkaloid derived from the club mossHuperzia serrata. Huperzine has been used in Chinese medicine to treatinflammation and fever. One source for Huperzine A is Sigma (H5777).Recently, huperzine was found to improve cognitive function, mentalalertness, focus, concentration, and memory. The beneficial effects ofhuperzine supplementation may be linked to its ability to enhance orimprove cholinergic transmission and by naturally decreasingacetylcholine hydrolysis through acetylcholinesterase inhibition and byincreasing neuronal cell survival and decreasing neuronal cell death.

Amounts of terpenes, sesquiterpene alkaloid compounds, and huperzine Aused within supplement foods can vary. For example, single servings ofeach terpene, sesquiterpene alkaloid compound, or huperzine A can beabout 0.01 μg/Kg to about 200 mg/Kg, about 0.05 μg/Kg to about 100mg/Kg, or about 0.1 μg/Kg to about 50 mg/Kg, or any intervening rangetherein. In some cases, a supplement food can include about 0.01 μg/Kg,about 0.03 μg/Kg, about 0.05 μg/Kg, about 0.07 μg/Kg, about 0.1 μg/Kg, 2μg/Kg, 5 μg/Kg, about 10 μg/Kg, about 50 μg/Kg, about 100 μg/Kg, about0.5 mg/Kg, about 1 mg/Kg, about 5 mg/Kg, about 10 mg/Kg, or about 30mg/Kg of the animal, or any intervening amount therein.

Medium-Chain Triglycerides (MCTs)

The supplement foods described herein can include medium-chaintriglycerides (MCTs). One example of a MCT that can be included iscaprylic acid. Caprylic acid has antibacterial, antiviral and antifungalproperties and it can help treat health problems associated with theovergrowth of yeast, such as vaginal yeast infections, Candida, andthrush. Caprylic acid can also be used to treat fungal infections, suchas ringworm.

The amounts of caprylic acid in the supplement food can vary. Forexample, a single dose of caprylic acid in the supplement food can beabout 0.1 mg/Kg to about 100 mg/Kg, or from about 1.0 mg/Kg to about 80mg/Kg, or from about 20 mg/Kg to about 60 mg/Kg, or any interveningamount therein. In some cases, a single dose of caprylic acid in thesupplement food can be about 1,000 to 3,000 milligrams per day. Onesource for caprylic acid is Sigma-Aldrich-PHR1202.

The caprylic acid can be included in the supplement food formulationswith a mixture of MCTs and/or in coconut oil.

MCTs include glycerol moieties substituted with C₆, C₈, C₁₀ and/or C₁₂mixtures of fatty acids. The percentages of triglycerides with C₆, C₈,C₁₀ and/or C₁₂ fatty acids in the MCT mixture can, for example, include30% to 100% of the total triglycerides, or 50% to 100%, 50% to 95%, and60% to 95% of the triglycerides. The proportion of C₆, fatty acids inthe MCT mixture can, for example, be about 0% to 3%, or about 2%. Theproportion of C₈ fatty acids in the MCT mixture can, for example, beabout 50% to 100%, or about 65-80%. The proportion of C₁₀ fatty acids inthe MCT mixture can, for example, be about 15% to 60%, or about 20-35%.The proportion of C₁₂ fatty acids in the MCT mixture can, for example,be about 0% to 3%, or about 2%. The MCT compositions can contain varyingamounts of free fatty acids. For example, the MCT compositions canamounts of free fatty acids of up to about 0.005/mEq/g (USP), forexample. In some cases, the MCTs can have a saponification value ofabout from 325-365 (USP) and an iodine value (USP Method II) of up toabout 1.0 gI₂/100 g. These specifications are not critical. MCT oils ofthis type are commercially available as lauric oils from coconut oil.

In some cases, most of the fatty acids are C₈ and C₁₀ fatty acids, forexample in ratios of about from 1:3 to 3:1. The exact specifications,including the relative proportions of C₆ to Cu medium chain fatty acids,will vary somewhat since the MCTs are obtained from natural sources.

Single servings of MCTs can include about 0.01 mg/Kg to about 500 mg/Kg,about 0.05 mg/Kg to about 300 mg/Kg, or about 0.1 mg/Kg to about 200mg/Kg of the animal, or any intervening range therein.

Coconut Oil

The supplement foods described herein can include coconut oil. Coconutoil can provide several benefits, including stimulation of the brain'scapacity to learn and categorize information, improved weight loss,increased energy, and reduced incidence of depression, Alzheimer's,anxiety, and dementia.

A single serving of coconut oil can range from about 1.0 mg/Kg to about100 mg/Kg, or from about 5 mg/Kg to about 80 mg/Kg, or from about 10mg/Kg to about 60 mg/Kg of the animal, or any intervening range therein.

Whole Plant Matter

The supplement foods described herein can include whole plant materials.For example, liquid, dried, or powdered whole plant materials fromplants such as Astragalus, fenugreek, monk fruit, and combinationsthereof.

Whole Astragalus plant materials from species such as Astragaluspropinquus (syn. Astragalus membranaceus, also known as huáing qì, bĕiqí, or huáing huā huáing qí) can be included in the supplement foodformulations. Astragalus propinquus is a perennial, flowering plant inthe family Fabaceae. It is one of about 50 fundamental herbs used intraditional Chinese medicine.

The whole plant or parts of the plant, such as the roots, can be used asa component of the supplements described herein. One method of preparinguseful components of Astragalus membranaceus involves extraction of theroots with 95% ethanol. For example, 10 kg of the roots of Astragalusmembranaceus can be extracted with 100 liters of 95% ethanol underreflux for 4 hours. The alcoholic solution can be discarded and thevegetal material can be extracted with 100 liters of 20% aqueousethanol. The hydroalcoholic extract solution can be concentrated undervacuum to a 10 liters volume at a temperature of 50° C. The aqueoussolution can be decolorized at 50° C. with 100 g of activated vegetalcharcoal. The solution can then be diluted under continuous agitationwith 40 liters of 95% ethanol. The resulting precipitate can becollected by decanting off the supernatant. The supernatant is discardedand the precipitate is set aside.

The solid vegetal material obtained by extraction with 20% ethanol, asdescribed above, can be treated with 50 liters 1N NaOH and left to standat 14° C. for 12 hours. The solution and the vegetal material can thenbe neutralized at pH 7 and heated to the boiling point for 2 hours. Thevegetal material can be filtered at a temperature of about 70° C. andthe extracted liquid can be decolorized with 100 g of activated vegetalcharcoal. The extracted liquid can then be concentrated to about 8liters. After filtering to remove the flocculated material, theconcentrate can be decanted into 10 liters of 95% ethanol. The resultingsolid precipitate can be collected and added to the material obtainedabove from the neutral hydroalcoholic extraction.

The pooled solid materials can be dissolved in 5 liters of water and theresulting solution can be poured under vigorous shaking into 20 litersof isopropanol. After drying under vacuum overnight, 420 g of the finalproduct can be obtained, which consists of a polysaccharide mixturecontaining substances with molecular weights ranging from 12,000 to500,000 daltons.

A single serving of Astragalus membranaceus plant materials in the inthe supplement food formulations can vary. For example, the amount ofAstragalus membranaceus plant materials can range from about 1 mg/Kg toabout 30 mg/Kg, or from about 3 mg/Kg to about 25 mg/Kg, or from about 5mg/Kg to about 20 mg/Kg of the animal, or any intervening range therein.In some cases, the amount of Astragalus membranaceus extract can beabout 14 mg/Kg per serving.

Whole fenugreek plant materials can also be included in the supplementfood formulations. Fenugreek is an annual plant in the family Fabaceae,with leaves consisting of three small obovate to oblong leaflets. It iscultivated worldwide as a semiarid crop, and its seeds are a commoningredient in dishes from the Indian Subcontinent in South Asia. Thewhole plant or parts of the plant, such as the seeds, can be used as acomponent of the supplements described herein.

For example, the seeds and/or other plant parts can be powdered usingpestle and mortar. The powdered plant materials can be incorporated intothe supplement foods. Alternatively, about 100 g of fenugreek powderedplant/seed material can be extracted with hexane to remove lipophiliccompounds using a Soxhlet apparatus. To remove pigments and todeactivate enzymes, the defatted powder can be boiled in ethanol for 20min. This treated powder can then be soaked in 10 liters of water andthe pH can be adjusted to 3.5 using 0.5 M hydrochloric acid. The mixturecan be stirred by a mechanical stirrer for 12 h and then filteredthrough filtration paper. The filtrate can be centrifuged (5000 g) andthe supernatant concentrated in vacuum to 50% of its initial volume. Theresulting supernatant solution can be mixed with the same volume of 96%ethanol and stored in a refrigerator for 4 h. The precipitated mucilagecan then be sedimented by centrifugation (5000 g). The collectedmucilage can be re-suspended in distilled water, agitated for 20 min andre-precipitated one more time to eliminate chloride ions and otherimpurities. Finally, the residue can be washed with diethyl ether andacetone and dried overnight at 45° C., resulting in an off-white powder.

A serving size of fenugreek plant materials in the in the supplementfood formulation can vary. For example, the amount of fenugreek plantmaterials can range from about 0.1 mg/Kg to about 100 mg/Kg, or fromabout 0.5 mg/Kg to about 75 mg/Kg, or from about 1 mg/Kg to about 60mg/Kg of the animal, or any intervening range therein. In many cases,the amount of fenugreek plant materials can be about 5.5 mg/Kg perserving or about 50 mg/Kg.

Monk fruit (Siraitia grosvenorii) is a small sub-tropical melon that isoften cultivated in Asia. Monk fruit is one of the sweetest fruitsaround. It is even sweeter than cane sugar but the sweetness in monkfruit has no calories. The sweet taste of monk fruit comes mainly frommogrosides, a group of triterpeneglycosides that make up about 1% of theflesh of the fresh fruit. Monk fruit is generally recognized as safe bythe FDA, and there are no restrictions on consuming the fruit or itsextracts.

A single serving of monk fruit is about 0.1 grams to 40 grams, or about0.2 to 30 grams, or about 0.3 to 20 grams, or about 0.5 to 20 grams, orany intervening range therein.

Plant Seeds

The supplement food formulations described herein can include seeds. Insome cases, the seeds can be in the form of a powder or a liquid extractof plant seeds, such as black seeds, chia seeds, flax seeds, raw pepitaseeds, Goji berries, and combinations thereof.

Black seeds are small, black, thick shaped seeds from the Nigella sativaflower. The seeds have a harsh taste and can burn the stomach if theseeds are not heated first. Black seeds can be heated at low heat withstirring until their taste becomes bland, and then ground into a powder.A single serving of black seeds is about 0.1 grams to 40 grams, or about1 to 30 grams, or about 2 to 20 grams, or about 2 to 10 grams, or anyintervening range therein.

Chia is Salvia hispanica, which is a species of flowering plant in themint family that is native to central and southern Mexico and Guatemala.A single serving of chia seeds is about 0.1 grams to 50 grams, or about1 to 40 grams, or about 5 to 35 grams, or about 10 to 35 grams, or about15 to 25 grams, or any intervening range therein.

Flax is Linum usitatissimum, which is a food and fiber crop cultivatedin cooler regions of the world. A single serving of flaxseeds is about 1grams to 100 grams, or about 3 to 75 grams, or about 5 to 60 grams, orabout 10 to 50 grams, or about 20 to 45 grams, or any intervening rangetherein.

Raw pepita seeds are raw pumpkin seeds. A single serving of pepita seedsis about 1 grams to 150 grams, or about 5 to 100 grams, or about 10 to75 grams, or about 15 to 50 grams, or about 20 to 45 grams, or anyintervening range therein.

Goji berry or wolfberry is the fruit of either the Lycium barbarum orLycium chinense, two closely related species of boxthorn in thenightshade family. A single serving of dried Goji berries is about 1grams to 500 grams, or about 5 to 300 grams, or about 10 to 250 grams,or about 20 to 200 grams, or about 30 to 150 grams, or any interveningrange therein.

Mushrooms

The supplement foods described herein can include mushrooms. Thesupplement foods described herein can include whole mushrooms or partsof mushrooms, such as the caps. For example, whole mushrooms (or partsthereof), can be processed for inclusion in the supplement foodsdescribed herein. The mushrooms in the mushroom extract can includeBrazillian Blazei (Agaricus blazei), Caterpillar Mushroom (Cordycepssinensis), Agarikon (Fomitopsis officinalis), Turkey Tail (Coriolusversicolor), Enoki (Flammulina velutipes), reishi (Ganoderma lucidum),Artist Conk (Ganoderma applanatum), Maitake (Grifola frondosa), Lion'sMane (Hericium erinaceus), Chaga (Inonotus obliquus), Shiitake(Lentinula edodes), Birch Polypore (Piptoporus betulinus), Mesimakobu(Phellinus linteus), Zhuling (Polyporus umbellatus), Fuling (Poriacocos), or a combination thereof.

In some cases, each serving of the supplement foods described herein caninclude about 25 to 500 mg of each type of mushroom, or about 40 to 400mg of each type of mushroom, or about 30 to 350 mg of each type ofmushroom, or any intervening range therein. However, larger or smalleramounts of the various mushrooms can also be included.

Brazillian Blazei (Agaricus blazei) is also known as ABM or Royal SunAgaricus. It was originally found in Brazil in a region where the peopleare known to live longer and healthier lives than the average. A singleserving of Agaricus blazei is about 0.1 grams to 40 grams, or about 0.5to 25 grams, or about 1 to 15 grams, or about 1.5 to 10 grams, or about1.5 to 7 grams, or any intervening range therein.

Caterpillar Mushroom (Cordyceps sinensis, renamed Ophiocordycepssinensis). A single serving of Ophiocordyceps sinensis is about 0.01grams to 20 grams, or about 0.05 to 15 grams, or about 0.1 to 10 grams,or about 0.5 to 5 grams, or about 1 to 3 grams, or any intervening rangetherein.

Agarikon (Fomitopsis officinalis, also known as Laricifomes officinalis)is a hefty, bracket fungus and can be found on the trunks of coniferoushosts, where it causes a brown-rot. The fruiting bodies persist for manyyears, becoming longer and longer as they grow. This species occursworldwide, and has gone by several common names including Agarikon,Quinine Conk, Larch Bracket Mushroom, Brown Trunk Rot and Eburiko. Asingle serving Agarikon (Fomitopsis officinalis) is about 0.1-20 gm/day,or about 0.25-10 gm/day, or about 0.5-5 gm/day, or any intervening rangetherein.

Turkey Tail (Coriolus versicolor, also known as Trametes versicolor) isa common polypore mushroom found throughout the world. A single servingof Coriolus versicolor is about 0.01 grams to 20 grams, or about 0.5 to15 grams, or about 1 to 12 grams, or about 3 to 10 grams, or about 5 to10 grams, or any intervening range therein.

Enoki (Flammulina velutipes) naturally grows on the stumps of theChinese Hackberry tree (Celtis sinensis, “enoki” in Japanese), but alsoon other trees, such as ash, mulberry and persimmon trees. A singleserving of Coriolus versicolor is about 0.1 grams to 200 grams, or about0.5 to 150 grams, or about 1 to 100 grams, or about 1 to 50 grams, orabout 2 to 10 grams, or any intervening range therein.

Reishi (Ganoderma lucidum) is a purplish-brown fungus with a long stalk,brown spores, and a fan-shaped cap with a shiny, varnish-coatedappearance. Reishi grows on decaying wood or tree stumps, preferring theJapanese plum tree but also found on oak. The mushroom is native toChina, Japan, and North America but is cultivated throughout other Asiancountries. Cultivation of reishi can be a long and complicated process.Reishi grows in six colors, each thought to have differentcharacteristics and known as: Aoshiba (blue reishi), Akashiba (redreishi), Kishiba (yellow reishi), Shiroshiba (white reishi), Kuroshiba(black reishi), and Murasakishiba (purple reishi). In some cases, thereishi in the supplement foods is red reishi. The amount of reishi(Ganoderma lucidum) in the in the supplement foods can vary. Forexample, a single daily serving of reishi (Ganoderma lucidum) can rangefrom about 0.5 to 100 grams, or about 1 to 50 grams, or about 2 to 20grams, or about 3 to 10 grams, or any intervening range therein.

Artist Conk (Ganoderma applanatum) is common in Maine, growing on oldersugar maples and many other hardwood trees usually persisting for years.When they are picked the interior reveals layers of pores that are likerings on a tree in describing age. Artist Conk (Ganoderma applanatum)contains polysaccharides and triterpenoids that have various medicinalimplications. They can be made into a medicinal tea by drying themushrooms thoroughly and grinding them with a meat grinder or other typeof grinder. The powder can be extracted with water, and the extract canbe dried. The amount of Artist Conk (Ganoderma applanatum) in the in thesupplement foods can vary. For example, a single daily serving of ArtistConk (Ganoderma applanatum) can range from about 0.5 to 100 grams, orabout 1 to 50 grams, or about 2 to 20 grams, or about 3 to 10 grams, orany intervening range therein.

Maitake (Grifola frondosa) is a polypore mushroom that grows in clustersat the base of trees, particularly oaks. The mushroom is commonly knownamong English speakers as hen of the woods, hen-of-the-woods, ram's headand sheep's head. It is typically found in late summer to early autumn.A single serving of Maitake (Grifola frondosa) is about 0.01 grams to 20grams, or about 0.05 to 15 grams, or about 0.1 to 10 grams, or about 0.3to 7 grams, or about 0.4 to 5 grams, or any intervening range therein.

Hericium erinaceus (also called lion's mane mushroom, bearded toothmushroom, satyr's beard, bearded hedgehog mushroom, pompom mushroom, orbearded tooth fungus) is an edible and medicinal mushroom belonging tothe tooth fungus group. Native to North America, Europe and Asia it canbe identified by its long spines (greater than 1 cm length), itsappearance on hardwoods and its tendency to grow a single clump ofdangling spines, or any intervening range therein. It is typically foundin late summer to early autumn. A single serving of Maitake (Grifolafrondosa) is about 0.01 grams to 20 grams, or about 0.05 to 15 grams, orabout 0.1 to 10 grams, or about 0.3 to 7 grams, or about 0.4 to 5 grams,or any intervening range therein.

Inonotus obliquus, commonly known as chaga mushroom, is a fungus in thefamily Hymenochaetaceae. It is parasitic on birch and other trees. Thesterile conk is irregularly formed and has the appearance of burntcharcoal. A single serving of chaga (Inonotus obliquus) is about 0.01grams to 20 grams, or about 0.05 to 15 grams, or about 0.1 to 10 grams,or about 0.3 to 7 grams, or about 0.3 to 5 grams, or any interveningrange therein.

Shiitake (Lentinula edodes) is an edible medicinal mushroom, well knownin the East. This mushroom is widespread in Japan and China, where ispart of the common alimentation. A single serving of shiitake (Lentinulaedodes) is about 0.1 grams to 30 grams, or about 0.5 to 20 grams, orabout 1 to 15 grams, or about 2 to 12 grams, or about 4 to 11 grams, orany intervening range therein.

Birch polypore (Piptoporus betulinus) grows from a single lateralattachment point on birch trees, being subglobose at first, thenexpanding to a bracket measuring approximately 10-20 cm across. It iswhite to begin with, the cap changing to a beige/tan color and thendarkening or greying with age. The underside is white and contains manypores which release their spores into the air. Spores land on exposedareas of birch trees, where branches have broken for example, and beginto grow hyphae which spread to form a mycelial network through the tree.It may be weakly parasitic on birch trees. A healthy tree will be ableto contain the spreading hyphae but in one that is aged or diseased thefungus will begin the gradual process of breaking it down. The fruitingbodies are annual, unlike some of our other common bracket fungi whichmay live for years, but they are often gnawed by insects before the endof this period so they are better picked young. A single serving ofBirch Polypore (Piptoporus betulinus) is about 0.1 grams to 30 grams, orabout 0.5 to 20 grams, or about 1 to 15 grams, or about 2 to 12 grams,or about 4 to 11 grams, or any intervening range therein.

Mesimakobu (Phellinus linteus) (Chinese “song gen” or Korean “sanghwang”or English “Meshima” or American English “black hoof mushroom”) isshaped like a hoof, has a bitter taste, and in the wild grows onmulberry trees. The stem's color ranges from dark brown to black. InKorean traditional medicine, the mushroom is consumed in the form of hottea. A single serving of Mesimakobu (Phellinus linteus) is about 1 gramsto 100 grams, or about 2 to 75 grams, or about 2 to 50 grams, or about 2to 25 grams, or about 3 to 15 grams, or any intervening range therein.

Zhuling (Polyporus umbellatus) is found in deciduous woodland regions innortheastern North America, Europe, and the temperate regions of China,commonly growing on dead and fallen trees and stumps. Good quality ZhuLing is heavy and solid. The surface is ideally smooth and black whilethe inside should be white and without holes. A single serving of Zhuling (Polyporus umbellatus) is about 0.01 grams to 20 grams, or about0.05 to 15 grams, or about 0.1 to 10 grams, or about 0.3 to 7 grams, orabout 0.3 to 5 grams, or any intervening range therein.

Fuling (Poria cocos) is a type of fungus related to Polyporus, whichusually grows on pine trees. Although it can range in color from whiteto pale red, the typical color of Poria is light brown, with striationson the outer skin. It is relatively soft to the touch, odorless, and hasslightly elastic properties. It is usually gathered from the tree, cutinto pieces of various length, and dried in the shade before being usedmedicinally. The amount of Fuling (Poria cocos) in the in the supplementfoods can vary. For example, a single daily serving of Fuling (Poriacocos) can range from about 0.5 to 100 grams, or about 1 to 50 grams, orabout 2 to 25 grams, or about 5 to 20 grams, or any intervening rangetherein.

Seaweed and/or Kelp

The supplement foods described herein can include seaweed and/or kelp.Edible seaweed typically comes in three varieties: brown, red and green.The most commonly eaten are the brown varieties such as kelp and wakame,followed by red seaweed, which includes nori (yep, which is what mostsushi chefs use). Seaweed contains vitamins A and C, and is also asource of potassium and calcium. Seaweed and kelp are also an excellentsource of iodine.

Examples of sources of seaweeds and/or kelp include pharmaceutical gradekelp extracts, kelp powders, seaweed powders, and/or kelp extracts.Other examples of sources of seaweeds and/or kelp include pharmaceuticalgrade Spirulina powder, pharmaceutical grade blue green algae powder(e.g., from AFA Lake & Sea), pharmaceutical grade Chlorella Powder(e.g., from Medical Technology Co., Ltd).

The amount of seaweed and/or kelp in the in the supplement foods canvary. For example, a single daily serving of seaweed or kelp can rangefrom about 0.005 to 200 grams, or about 0.01 to 150 grams, or about 0.02to 100 grams, or about 0.5 to 20 grams, or any intervening rangetherein. In some cases, a single serving of seaweed or kelp can be about70 mg.

Freshness Preservation Compound(s)

The supplement foods described herein can include ingredients thatmaintain or improve the freshness of the supplement food formulation.Examples of such freshness preservation ingredients can be potassiumbenzoate, β-cyclodextrin, γ-cyclodextrin, or a combination thereof.

The amounts of freshness preservation ingredients can vary. For example,the freshness preservation ingredients can be included in the supplementfoods at about 0.01% by weight to about 5% by weight of the supplementfood weight. In some cases, the freshness preservation ingredients canbe included in the supplement foods at about 0.05% by weight to about 3%by weight, or at about 0.1% by weight to about 2% by weight of thesupplement food weight

Flavoring Agents

The supplement foods can also contain any one of a variety of knownflavoring agents. For example, the supplement can contain flavoringagents. Exemplary flavoring agents include natural or artificialflavorings such as strawberry, plum, banana, blueberry, cherry,cinnamon, coconut, coffee, chocolate (e.g., dark chocolate), raspberry,grape, green apple, lemon, mango, menthol, mint, mojito, orange, peach,pear, pineapple, pomegranate, root beer, tobacco, vanilla, watermelon,and combinations thereof. The flavoring agents can also include complexsugars such as fructose, and other flavoring agents known in the arts,such as polysaccharides.

Artificial sweeteners can also be used. It may be desirable, however,for the supplement to be comprised substantially, even entirely, ofnaturally occurring sweeteners and/or no sweeteners. There is no reallimit on the amount of flavoring agent but the supplements have a mildtaste that generally needs no added flavoring agents. Enough flavoringagent can be included to produce a supplement having a desirable taste.Methods are available that can be used to determine what flavoringagents, and levels thereof, should be included in the supplement. Thecomposition can be provided free of flavoring agents as well.

Additional Ingredients

The supplements described herein can also contain additionalingredients. For example, the supplements can include extracts fromplants such as yew, pine, hemlock, ginger, poppy, or combinationsthereof. The supplements can also contain ingredients such as vincaalkaloids (e.g., benzophenanthridine alkaloids), phenolics, xanthones,other terpenoids, paclitaxel, carnosic acid, Noscapine, phytoalexins,sulforaphane, luteolin, betulinic acid, lunasin, plumbagin, gallicacid-based steroidal phenstatin analogs, cryptotanshinone, ursolic acid,coumarins, ginsenosides, withanolides, paclitaxel, carboplatin, pomolicacid, 1,4-naphthoquinones (e.g., from Diospyros L.), 4-shogaol (e.g.,from ginger), sanguinarine, α-mangostin, magnolol, or any combinationthereof (see, e.g., Park, EXCLI Journal 11:386-389 (2012) for furtherinformation on some of these ingredients).

Carrier

The supplements described herein are generally liquid, powdered, or foodformulation that may require no additives, additional solvents, orcarriers. The supplements can be a concentrated formulation that can bediluted, combined or dissolved in a carrier or added to a food. In somecases, the components and/or the completed supplement formulations canbe freeze dried or concentrated to reduce the volume of the supplements(e.g., for ease of shipping or to generate a desired serving size). Suchdry or concentrated supplement formulations can be combined with acarrier, drink, or food.

The carrier can be any substance that can form a homogenous mixture withthe supplement components, and that can be dispensed in a manner toprovide a predetermined serving size. The carrier should not interferewith any of the beneficial ingredients of the supplement or inhibit thedesired activity. The amount of carrier is entirely within thediscretion of the formulator, although higher levels of carrier mayexcessively dilute the supplement. In addition, certain levels ofcarrier may be used to obtain a desired serving size, a desired taste,or a desired texture or consistency. For example, the supplement cancomprise about 10 wt % carrier to about 50 wt %.

Supplement food formulations can include various sweetening agents ornatural carbohydrates, as is the case with conventional drinksPreferably, the natural carbohydrate can include monosaccharides such asglucose and fructose, di-saccharides such as maltose and sucrose,polysaccharides such as dextrin and cyclodextrin, and sugar alcoholssuch as xylitol, sorbitol and erythritol. The sweetening agent caninclude natural substances such as thaumatin and stevioside andsynthetic substances such as saccharin and aspartame. The carbohydratescan be added in the ratio of from 0.01 to 0.04 g per 100 mL of thepresent composition, and more preferably, in the ratio of from 0.02 to0.03 g per 100 g of the composition.

The composition of the present invention can further include variousnutrients, vitamin, electrolytes, flavoring agents or coloring agentsand pectic acids and its salts, alginic acid and its salts, protectivecolloids, viscosity enhancers, pH controllers, stabilizers,preservatives, glycerin, alcohols, carbonating agents for carbonateddrinks. In some cases, the supplement can include additional protein(whey, pea proteins, casein, hemp protein, or combinations thereof).

The supplement can include additional ingredients, such aspreservatives, coloring agents, thickening agents, and other agentstypically used in such supplements and known to those of skill in theart, that do not affect the activity of the above described activeingredients.

The supplement food can be formulated into bars, rolls, buns, breads,chocolates, candies, snack items, cookies, noodles, gums, dairy productssuch as ice cream, soups, drinks, teas, alcohols, juices, and sportsdrink.

The supplement foods can include natural fruit juices, fruit juicedrinks and fresh vegetable slurries. The constituents mentioned abovecan be used independently or in combination Generally, the additive canbe often added in a ratio of (but not limited to) from 0.01 to 0.1 wtparts per 100 wt parts of the present composition,

The supplement can be prepared for oral administration, and can be inthe form of a liquid drink. The supplement can be formulated to be takenas a daily supplement. For instance, the serving size can be at leastabout one-half fluid oz., or at least about 1 fluid oz., or at least 2fluid oz., or at least 4 fluid oz. For example, when the supplement isprovided with a 1 fl. oz. serving size, a full month supply can be soldin a single 32 fl. oz. bottle. These volumes correspond to thesupplement in a drinkable fluid. It is contemplated that the consumermay shake the supplement prior to consumption to obtain a morehomogenous mixture. It also is contemplated that the supplement could bediluted by the consumer. Of course, the supplement could also be dilutedby the manufacturer. For instance, the supplement could be diluted andsold as a beverage, or it could be added to a beverage prior to sale.

The supplement food could also be provided as a health bar, where singleservings of the various ingredients are formulated into a nutritionalbar.

The supplement food could also be provided in the form of a gel,capsule, or tablet in which case the serving size could be distributedover several gels, several capsules, or several tablets.

When formulated for human consumption, the supplement should be freefrom any substances that are unsuitable for human consumption.Substances that are typically present only in topically appliedcompositions that render the composition unsuitable for consumption canbe eliminated from the supplement. For example, some substances that canbe excluded from the composition include emollients, petroleum-basedsubstances, and fragrances and perfumes that are unintended andunsuitable for human consumption.

An example of a Supplement formulation is shown in Table 2.

TABLE 2 Supplement Composition mg per mg per mg per Kg 70 Kg 100 Kg BodyWeight Body Weight Body Weight Component (1 Serving) (1 Serving) (1Serving) Amino Acids Alanine 5.8 406 588 Arginine 8.18 572.6 818Aspartic Acid 1.092 76.44 1092 Cystine 2.88 201.6 288 Glutamic Acid2.065 144.55 206.5 Glycine 3.78 264.6 378 Histidine 2.7 189 270Isoleucine 7 490 700 Lysine 8 614 854 Leucine 10.91 763.7 1091Methionine 2.76 193.2 276 Phenylalanine 11.2 784 1120 Serine 11.2 7841120 Proline 7.32 512.4 732 Threonine 5.7 399 570 Tryptophan 1.87 130.9187 Tyrosine 4.92 344.4 492 Valine 7.22 505.4 722 Fulvic-humic acids 201400 2000 Multi-minerals 20 25 30 β-Alanine 8 560 8002,3-Diaminopropionic acid 0.05 3.5 5 α-Aminoisobutyric acid 0.06 4.2 6N-Methylglycine 0.06 4.2 6 (sarcosine) Ornithine 0.06 4.2 6 Citrulline10 700 1000 t-Butylalanine 1 70 100 t-Butylglycine 1 70 100N-methylisoleucine 0.1 7 10 Phenylglycine 0.01 0.7 1 Cyclohexylalanine0.035 2.45 3.5 Norleucine 0.25 10.5 15 Naphthylalanine 0.1 7 10Pyridylalanine 0.1 7 10 3-Benzothienyl alanine 0.06 4.2 64-Chlorophenylalanine 0.25 17.5 25 2-Fluorophenylalanine 0.15 10.5 153-Fluorophenylalanine 0.15 10.5 15 4-Fluorophenylalanine 0.15 10.5 15Penicillamine 3.75 262.5 375 1,2,3,4-Tetrahydro- 0.25 17.5 25isoquinoline-3-carboxylic acid E-2-thienylalanine 0.06 4.2 6 Methioninesulfoxide 4.7 μg 329 μg 470 μg Homoarginine 1.28 89.6 125 N-acetyllysine 6 420 600 2,4-Diamino butyric acid 0.01 0.7 1D-Aminophenylalanine 1 70 100 N-methylvaline 0.07 4.9 7 Homocysteine 170 100 Homoserine 0.3 21 30 Amino hexanoic acid 0.01 0.7 1 Amino valericacid 1.28 89.6 128 2,3-Diaminobutyric acid 0.01 0.7 1Phosphatidylinositol Phosphatidylinositol 0.6 42 60 Coconut ExtractionsCaprylic Acid 15 1050 1500 MCT 25 1750 2500 Coconut Oil 40 2800 4000Glycerin Glycerin 45 3150 4500 Terpenes/Sesquiterpene alkaloidsAlpha-Humulene 2.5 175 250 Alpha-Phellandrene 10 700 1000 Alpha-pinene4.5 315 450 Alpha-Terpinene 2.5 175 250 Alpha-Terpinolene 26 1820 2600Beta-Myrcene 0.7 49 70 Beta-pinene 5 350 500 Camphene 0.6 42 60Cis-Ocimene 2 140 200 Delta-3 Carene 1.1 77 110 Limonene 30 2100 3000Sabinene 2.5 175 250 Trans-Caryophyllene 1.4 98 140 Trans-Ocimene 1.1 77110 Y-Terpinene 1.5 105 150 1.8-Cineole 1.8 126 180 Perillyl alcohol 170 100 Flax seeds, Raw pepita Cold Pressed Plant/Seed Oil seeds, Chiaseeds Omega-6 linoleic acid (LA) 7 490 700 Omega-3 alpha-linolenic 2.5175 250 acid (ALA) Omega-9 2 140 200 Omega-6 gamma linolenic 0.5 35 500acid (GLA) Omega-3 stearidonic acid 0.25 175 250 (SDA) Black Seeds Blackseeds 4 280 400 Goji berries Goji berries 2 140 200 Seaweed and/or kelpSeaweed and/or kelp 1 70 100 Fenugreek 95% + Fenugreek extract 48 33604800 Monk Fruit 95% + monk fruit extract 5 350 100 Artemisia ludoviciana95% + Artemisia 5 350 500 ludoviciana extract Mushroom ExtractsBrazillian Blazei (Agaricus 2 70-140 100-200 blazei) CaterpillarMushroom 2 70-140 100-200 (Cordyceps sinensis, renamed Ophiocordycepssinensis) Enoki (Flammulina 2 70-140 100-200 velutipes) Agarikon(Fomitopsis 2 70-140 100-200 officinalis, also known as Laricifomesofficinalis) Turkey Tail (Coriolus 2 70-140 100-200 versicolor, alsoknown as Trametes versicolor) Shitake 2 70-140 100-200 Red Reishi 4140-280  200-400 Fuling (Poria cocos) 2 70-140 100-200 Zhu ling(Polyporus 2 70-140 100-200 umbellatus) Mesimakobu (Phellinus 2 70-140100-200 linteus) Birch polypore (Piptoporus 2 70-140 100-200 betulinus)Inonotus obliquus 2 70-140 100-200 Hericium erinaceus 2 70-140 100-200Maitake (Grifola frondosa) 4 140-280  200-400 Artist Conk (Ganoderma 270-140 100-200 applanatum) Freshness preservation compound(s) Potassiumbenzoate 0.02 1.4 2 β-cyclodextrin 0.02 1.4 2 γ-cyclodextrin 0.02 1.4 2

The amounts shown in Table 2 can be varied by about 5%, or by about 10%,or by about 20%, or by about 50%. The Supplement has no negative sideeffects at even high dosages. Subjects can take the supplement 1 to 7times a day, or 1 to 5 three times a day, or 1 to 3 three times a day.

Benefits of the Supplement

Patients report that the supplement described herein provides severalbenefits, which are described below.

-   -   Hunger reduction by ⅓ to ½ with daily usage;    -   Meal replacement;    -   Belly (abdominal) fat reduction;    -   Energy and mentation (more focused) increases within one week;    -   Gastrointestinal tract normalization with daily use;    -   Immune stimulation/supplementation (e.g., users did not get sick        when others around them were getting sick; often complete        avoidance of illness compared to family and friends in same        proximity);    -   Cancer patients sent home to die lived months to years longer        using this product after they failed life-saving and often ‘last        ditch’ radiation and chemotherapy:        -   Specific cancers where this worked were breast, colon,            prostate and glioblastoma; and        -   Some complete tumor remission was noted in terminally ill            patients.

Methods

Also described herein is a method of administering any of thesupplements described herein to a subject. The subject can be a human,domesticated animal, experimental animal, or zoo animal.

The supplements can be liquid or solid. For example, the compositionscan be dried and mixed with foods. In some cases, the supplements are inliquid form.

The supplements can be administered in an amount effective to reducepain, reduce the incidence and symptoms of disease (e.g., of cancer,flu, colds), increase energy, improve sleep patterns, increase activitylevels, reduce extremity numbness, improve digestion, reducegastrointestinal problems (e.g., reduce constipation, bloating,diarrhea), reduce the incidence or severity of headaches, reduce thefrequency or severity of seizures, reduce weight gain, facilitate weightloss, or combinations thereof, compared to healthy subjects, compared toa subject of the same species that does not receive the supplement, orcompared to the subject's own experience prior to taking thesupplements.

For example, a single serving of the supplement can be about 0.25 fluidounces to about 12 fluid ounces, or about 0.5 fluid ounces to about 8fluid ounces, or 1 fluid ounces to about 6 fluid ounces.

The supplements can be administered or taken at least once per week forfour weeks. In some the supplements are routinely administered oringested daily, biweekly, triweekly, weekly and/or via a sustainedregimen over time (e.g., over one or more months, or over one or moreyears).

The following Examples illustrate some aspects of the invention. Notethat the composition described herein that is administered is referredto as the Supplement.

Example 1: An Example of a Supplement Formulation

Table 2, below, shows an example of a Supplement composition.

TABLE 2 Supplement Composition mg per mg per mg per Kg 70 Kg 100 Kg BodyWeight Body Weight Body Weight Component (1 Serving) (1 Serving) (1Serving) Amino Acids Alanine 5.8 406 588 Arginine 8.18 572.6 818Aspartic Acid 1.092 76.44 1092 Cystine 2.88 201.6 288 Glutamic Acid2.065 144.55 206.5 Glycine 3.78 264.6 378 Histidine 2.7 189 270Isoleucine 7 490 700 Lysine 8 614 854 Leucine 10.91 763.7 1091Methionine 2.76 193.2 276 Phenylalanine 11.2 784 1120 Serine 11.2 7841120 Proline 7.32 512.4 732 Threonine 5.7 399 570 Tryptophan 1.87 130.9187 Tyrosine 4.92 344.4 492 Valine 7.22 505.4 722 Fulvic-humic acids 201400 2000 Multi-minerals 20 25 30 β-Alanine 8 560 8002,3-Diaminopropionic acid 0.05 3.5 5 α-Aminoisobutyric acid 0.06 4.2 6N-Methylglycine 0.06 4.2 6 (sarcosine) Ornithine 0.06 4.2 6 Citrulline10 700 1000 t-Butylalanine 1 70 100 t-Butylglycine 1 70 100N-methylisoleucine 0.1 7 10 Phenylglycine 0.01 0.7 1 Cyclohexylalanine0.035 2.45 3.5 Norleucine 0.25 10.5 15 Naphthylalanine 0.1 7 10Pyridylalanine 0.1 7 10 3-Benzothienyl alanine 0.06 4.2 64-Chlorophenylalanine 0.25 17.5 25 2-Fluorophenylalanine 0.15 10.5 153-Fluorophenylalanine 0.15 10.5 15 4-Fluorophenylalanine 0.15 10.5 15Penicillamine 3.75 262.5 375 1,2,3,4-Tetrahydro- 0.25 17.5 25isoquinoline-3-carboxylic acid E-2-thienylalanine 0.06 4.2 6 Methioninesulfoxide 4.7 μg 329 μg 470 μg Homoarginine 1.28 89.6 125 N-acetyllysine 6 420 600 2,4-Diamino butyric acid 0.01 0.7 1D-Aminophenylalanine 1 70 100 N-methylvaline 0.07 4.9 7 Homocysteine 170 100 Homoserine 0.3 21 30 Amino hexanoic acid 0.01 0.7 1 Amino valericacid 1.28 89.6 128 2,3-Diaminobutyric acid 0.01 0.7 1Phosphatidylinositol Phosphatidylinositol 0.6 42 60 Coconut ExtractionsCaprylic Acid 15 1050 1500 MCT 25 1750 2500 Coconut Oil 40 2800 4000Glycerin Glycerin 45 3150 4500 Terpenes/Sesquiterpene alkaloidsAlpha-Humulene 2.5 175 250 Alpha-Phellandrene 10 700 1000 Alpha-pinene4.5 315 450 Alpha-Terpinene 2.5 175 250 Alpha-Terpinolene 26 1820 2600Beta-Myrcene 0.7 49 70 Beta-pinene 5 350 500 Camphene 0.6 42 60Cis-Ocimene 2 140 200 Delta-3 Carene 1.1 77 110 Limonene 30 2100 3000Sabinene 2.5 175 250 Trans-Caryophyllene 1.4 98 140 Trans-Ocimene 1.1 77110 Y-Terpinene 1.5 105 150 1.8-Cineole 1.8 126 180 Perillyl alcohol 170 100 Flax seeds, Raw pepita Cold Pressed Plant/Seed Oil seeds, Chiaseeds Omega-6 LA 7 490 700 Omega-3 ALA 2.5 175 250 Omega-9 2 140 200Omega-6 GLA 0.5 35 500 Omega-3 SDA 0.25 175 250 Black Seeds Black seeds4 280 400 Goji berries Goji berries 2 140 200 Seaweed and/or kelpSeaweed and/or kelp 1 70 100 Fenugreek 95% + Fenugreek extract 48 33604800 Monk Fruit 95% + monk fruit extract 5 350 100 Artemisia ludoviciana95% + Artemisia 5 350 500 ludoviciana extract Mushroom ExtractsBrazillian Blazei (Agaricus 2 70-140 100-200 blazei) CaterpillarMushroom 2 70-140 100-200 (Cordyceps sinensis, renamed Ophiocordycepssinensis) Enoki (Flammulina 2 70-140 100-200 velutipes) Agarikon(Fomitopsis 2 70-140 100-200 officinalis, also known as Laricifomesofficinalis) Turkey Tail (Coriolus 2 70-140 100-200 versicolor, alsoknown as Trametes versicolor) Shitake 2 70-140 100-200 Red Reishi 4140-280 200-400 Fuling (Poria cocos) 2 70-140 100-200 Zhu ling(Polyporus 2 70-140 100-200 umbellatus) Mesimakobu (Phellinus 2 70-140100-200 linteus) Birch polypore (Piptoporus 2 70-140 100-200 betulinus)Inonotus obliquus 2 70-140 100-200 Hericium erinaceus 2 70-140 100-200Maitake (Grifola frondosa) 4 140-280 200-400 Artist Conk (Ganoderma 270-140 100-200 applanatum) Freshness preservation compound(s) Potassiumbenzoate 0.02 1.4 2 β-cyclodextrin 0.02 1.4 2 γ-cyclodextrin 0.02 1.4 2

Table 3, below, shows dosages of the Supplement that can be taken 2 to 3times per day.

TABLE 3 Supplement Dosages OZ per Kg OZ per 100 Kg OZ per 70 Kg BodyWeight Body Weight Body Weight (1 Serving) (1 Serving) (1 Serving) 5 mlto 20 ml 1 oz to 3 oz 1 oz to 3 oz

Example 2: Manufacture of the Supplement

This Example illustrates a method of making the Supplement.

Tables 4 and 5 list the components of the Supplement in groups, wherethe groups of components are referred to as Mixtures. For example, thecomponents of a Mixture are sufficiently similar in chemical andphysical properties to be handled together in the manufacturing process.

In Table 4, the amounts of each component that can be included in agallon of the Supplement are listed opposite the component.

TABLE 4 Mixtures of Components # Component Amount 1 LQ Mixture add 1st 2Vegetable Glycerin (48 oz per gallon) 3 Coconut oil (28 oz per gallon) 45 6 MCT OIL Mixture add 2nd 7 Oil (MCT) 15 ml/100 Kg (6 oz per gallon)Caprylic/Capric/Triglycerides 8 8-Carbon MCT 15 ml/100 Kg (6 oz pergallon) 9 MCT Medium Chain Triglycerides 15 ml/100 Kg (6 oz per gallon)10 11 12 Amino Acid Mixture add 5th 13 All in one multiple vitamin, 30ml/100 Kg (per gallon) mineral, and antioxidant 14 Glycine 1 gram/100 Kg(512 grams per gallon) 15 Humic Acids 15 ml/100 Kg (1024 grams pergallon) 16 Fulvic 15 ml/100 Kg (1024 grams per gallon) 17 Isoleucine 3grams/100 Kg (1024 grams per gallon) 18 L-Tyrosine 1000 mg/100 Kg 19 D-Aspartic Acid 2000 mg/100 Kg (512 grams per gallon) 20 L-Tryptophan ¼tsp/1 gram (512 grams per gallon) 21 L-Valine 5 ml/2000 mg (512 gramsper gallon) 22 L-Proline 2 grams/100 Kg (1024 grams per gallon) 23L-Histidine 500 mg/100 Kg (256 grams per gallon) 24 L-Lysine 550 mg/100Kg (287 grams per gallon) 25 N-Acetyl L-Cysteine 1000 mg/100 Kg (512grams per gallon) 26 L-Methionine 500 mg/100 Kg (256 grams per gallon)27 L-Serine 5 ml/2000 mg/100 Kg (512 grams per gallon) 28 Beta Alanine4000 mg/100 Kg (1024 grams per gallon) 29 Plant Protein 4grams 30β-Alanine 80 g per gallon 31 2,3-Diaminopropionic acid 50 g per gallon32 α-Aminoisobutyric acid 60 g per gallon 33 N-Methylglycine (sarcosine)60 g per gallon 34 Ornithine 60 g per gallon 35 Citrulline 100 g pergallon 36 t-Butylalanine 100 g per gallon 37 t-Butylglycine 100 g pergallon 38 N-methylisoleucine 30 g per gallon 39 Phenylglycine 10 g pergallon 40 Cyclohexylalanine 30 g per gallon 41 Norleucine 150 g pergallon 42 Naphthylalanine 100 g per gallon 43 Pyridylalanine 100 g pergallon 44 3-Benzothienyl alanine 60 g per gallon 454-Chlorophenylalanine 250 g per gallon 46 2-Fluorophenylalanine 150 gper gallon 47 3-Fluorophenylalanine 150 g per gallon 484-Fluorophenylalanine 150 g per gallon 49 Penicillamine 375 g per gallon50 1,2,3,4-Tetrahydro-isoquinoline- 250 g per gallon 3-carboxylic acid51 E-2-thienylalanine 60 g per gallon 52 Methionine sulfoxide 4700 μgper gallon 53 Homoarginine 454 g per gallon 54 N-acetyl lysine 600 g pergallon 55 2,4-Diamino butyric acid 10 g per gallon 56D-Aminophenylalanine 100 g per gallon 57 N-methylvaline 70 g per gallon58 Homocysteine 100 g per gallon 59 Homoserine 300 g per gallon 60 Aminohexanoic acid 10 g per gallon 61 Amino valeric acid 800 g per gallon 622,3-Diaminobutyric acid 10 g per gallon 63 64 Powder Mixture add 6th 65Frankincense powder 1500 mg/100 Kg Boswellia Serrata (454 grams pergallon) 66 Artemisia ludoviciana 300 mg/¼ tsp/100 Kg (454 grams pergallon) 67 Black Seeds 10 ml/kg (227 grams per gallon) 68 69 Goji berryMixture add 10th 70 Goji berries 1500 mg/100 Kg (454 grams per gallon)71 72 Monk Fruit Mixture add 9th 73 Monk Fruit 1500 mg/100 Kg (454 gramsper gallon) 74 75 Seaweed and/or kelp Mixture add 8th 76 Seaweed and/orkelp 1500 mg/100 Kg 18 oz (454 grams per gallon) 77 78 Mushroom ExtractMixture add 7th 79 Brazillian Blazei (Agaricus blazei) 5 ml/2000 mg/100Kg (512 grams per gallon) 80 Caterpillar Mushroom (Cordyceps 5 ml/2000mg/100 Kg sinensis, renamed Ophiocordyceps (512 grams per gallon)sinensis) 81 Enoki (Flammulina velutipes) 5 ml/2000 mg/100 Kg (512 gramsper gallon) 82 Agarikon (Fomitopsis officinalis, also 5 ml/2000 mg/100Kg known as Laricifomes officinalis) (512 grams per gallon) 83 TurkeyTail (Coriolus versicolor, also 5 ml/2000 mg/100 Kg known as Trametesversicolor) (512 grams per gallon) 84 Shitake 5 ml/2000 mg/100 Kg (512grams per gallon) 85 Red Reishi 5 ml/2000 mg/100 Kg (512 grams pergallon) 86 Fuling (Poria cocos) 5 ml/2000 mg/100 Kg (512 grams pergallon) 87 Zhu ling (Polyporus umbellatus) 5 ml/2000 mg/100 Kg (512grams per gallon) 88 Mesimakobu (Phellinus linteus) 5 ml/2000 mg/100 Kg(512 grams per gallon) 89 Birch polypore (Piptoporus betulinus) 5ml/2000 mg/100 Kg (512 grams per gallon) 90 Inonotus obliquus 5 ml/2000mg/100 Kg (512 grams per gallon) 91 Hericium erinaceus 5 ml/2000 mg/100Kg (512 grams per gallon) 92 Maitake (Grifola frondosa) 5 ml/2000 mg/100Kg (512 grams per gallon) 93 Artist Conk (Ganoderma applanatum) 5ml/2000 mg/100 Kg (512 grams per gallon) 94 95 Terpenes/Sesquiterpenealkaloid Mixture add 3rd 96 Alpha-Humulene 12 ml/Kg (18 oz per gallon)97 Alpha-Phellandrene 12 ml/Kg (18 oz per gallon) 98 Alpha-pinene 12ml/Kg (18 oz per gallon) 99 Alpha-Terpinene 12 ml/Kg (18 oz per gallon)100 Alpha-Terpinolene 12 ml/Kg (18 oz per gallon) 101 Beta-Myrcene 12ml/Kg (18 oz per gallon) 102 Beta-pinene 12 ml/Kg (18 oz per gallon) 103Camphene 12 ml/Kg (18 oz per gallon) 104 Cis-Ocimene 12 ml/Kg (18 oz pergallon) 105 Delta-3 Carene 12 ml/Kg (18 oz per gallon) 106 Limonene 12ml/Kg (18 oz per gallon) 107 Sabinene 12 ml/Kg (18 oz per gallon) 108Trans-Caryophyllene 12 ml/Kg (18 oz per gallon) 109 Trans-Ocimene 12ml/Kg (18 oz per gallon) 110 Y-Terpinene 12 ml/Kg (18 oz per gallon) 1111.8-Cineole 12 ml/Kg (18 oz per gallon) 112 Perillyl alcohol 12 ml/Kg(18 oz per gallon) 113 114 Cold Pressed Plant/Seed Oil Mixture add 4th115 Flax seeds, Raw pepita seeds, (12 oz per gallon)/(454 grams pergallon Chia seeds 116 Omega-6 LA (12 oz per gallon)/(454 grams pergallon 117 Omega-3 ALA (12 oz per gallon)/(454 grams per gallon 118Omega-9 (12 oz per gallon)/(454 grams per gallon 119 Omega-6 GLA (12 ozper gallon)/(454 grams per gallon 120 Omega-3 SDA (12 oz pergallon)/(454 grams per gallon 121 122 Freshness preservation compoundMixture add 11th 123 Potassium benzoate 8 grams per gallon 124β-cyclodextrin 8 grams per gallon 125 γ-cyclodextrin 8 grams per gallon

Table 5 illustrates the Mixtures that can used in a manufacturingprocess for making the Supplement.

TABLE 5 Mixtures for Manufacturing LQ Mixture add 1st  1. Pharmaceuticalgrade vegetable glycerin oil.  2. Coconut oil MCT Oil Mixture add 2nd 3. Oil (MCT) Caprylic acid/Capric acid/Triglycerides  4. 8-Carbon MCT 5. MCT Medium Chain Triglycerides Terpenes/Sesquiterpene alkaloidsMixture add 3rd  6. Alpha-Humulene  7. Alpha-Phellandrene  8.Alpha-pinene  9. Alpha-Terpinene 10. Alpha-Terpinolene 11. Beta-Myrcene12. Beta-pinene 13. Camphene 14. Cis-Ocimene 15. Delta-3 Carene 16.Limonene 17. Sabinene 18. Trans-Caryophyllene 19. Trans-Ocimene 20.Y-Terpinene 21. 1.8-Cineole 22. Perillyl alcohol Cold Pressed Plant/SeedOil Mixture add 4th Flax seeds, Raw pepita seeds, Chia seeds 23. Omega-6LA 24. Omega-3 ALA 25. Omega-9 26. Omega-6 GLA 27. Omega-3 SDA Aminoacids Mixture add 5th 28. to 49. Combine components 13 to 62 from Table4 Powder Mix Mixture add 6th 50. Frankincense powder Boswellia Serrata51. Artemisia ludoviciana 52. Black Seeds Mushroom Extract MixtureCombine in Order and add 7th 53. to 67. Combine components 79 to 93 fromTable 4 Seaweed and/or kelp Mixture Combine in Order and add 8th 68.Seaweed and/or kelp Monk Fruit Mixture Combine in Order and add 9th 69.Monk Fruit Goji berry Mixture Combine in Order and add 10th 70. Gojiberries Freshness preservation compound(s) Mixture Combine in Order andadd 11th 71. Potassium benzoate 72. β-cyclodextrin 73. γ-cyclodextrin

The following procedure was used to prepare the supplement.

The LQ Mixture was formed by mixing (at 300-1200 rpm) 48 oz. per gallonpharmaceutical grade vegetable glycerin oil (component #1) and 28 oz.per gallon coconut oil (component #2) together, with heating up to about118° F. (47-48° C.) to combine the ingredients.

The MCT/Coconut oil mixture was formed by mixing (at 300-1200 rpm) 15ml/100 Kg (6 oz per gallon) each of the following: Oil (MCT) Caprylicacid/Capric acid/Triglycerides, 8-Carbon MCT, and MCT Medium ChainTriglycerides (components 3, 4, and 5) together with heating up to about118° F. (47-48° C.) to combine the ingredients.

The Terpenes/Sesquiterpene alkaloid mixture was formed by mixing (at300-1200 rpm) 12 ml/Kg (18 oz per gallon) of each of components 6 to 22shown in Table 5 together with heating up to about 118° F. (47-48° C.).

The Cold Pressed Plant/Seed Oil mixture was formed by mixing (at300-1200 rpm) 12 oz per gallon)/(454 grams per gallon) of each ofcomponents 23 to 27 shown in Table 5 together with heating up to about118° F. (47-48° C.). Flax seeds, raw pepita seeds, and/or chia seeds cana source of the Cold Pressed Plant/Seed Oil. Optionally, whole orpowdered flax seeds, raw pepita seeds, and/or chia seeds can be includedin the Cold Pressed Plant/Seed Oil Mixture.

The Amino Acid mixture was formed by mixing (at 300-1200 rpm) each ofcomponents 13 to 62 shown in Table 4 using the amounts shown in Table 4with heating up to about 118° F. (47-48° C.).

The Powder Mixture was formed by mixing (at 300-1200 rpm) 1500 mg/100 Kg(454 grams per gallon) of Frankincense powder Boswellia serrata(component 50), with 300 mg/¼ tsp/100 Kg (454 grams per gallon) ofArtemisia ludoviciana (component 51), and with 10 ml/kg (227 grams pergallon) (50 to 52) of Black Seeds (component 52), with heating up toabout 118° F. (47-48° C.).

The Mushroom Extract mixture was formed by mixing (at 300-1200 rpm) 5ml/2000 mg/100 Kg (512 grams per gallon) of each of components 79 to 93from Table 4 with heating up to about 118° F. (47-48° C.).

The Seaweed and/or Kelp Mixture was formed by mixing (at 300-1200 rpm)18 oz (454 grams per gallon; 1500 mg/100 Kg) of the seaweed and/or kelpwith heating up to about 118° F. (47-48° C.).

The Monk Fruit Mixture was formed by mixing (at 300-1200 rpm) 1500mg/100 Kg (454 grams per gallon) Monk Fruit with heating up to about118° F. (47-48° C.).

The Goji berry Mixture was formed by mixing (at 300-1200 rpm) 1500mg/100 Kg (454 grams per gallon) Goji berries with heat up to about 118°F. (47-48° C.).

The Freshness preservation compound Mixture was formed by mixing (at300-1200 rpm) 8 grams per gallon of each of potassium benzoate,β-cyclodextrin, and/or γ-cyclodextrin with heating up to about 118° F.(47-48° C.). In some cases, one of the following was included in theSupplement: potassium benzoate, β-cyclodextrin, or γ-cyclodextrin. Insome cases, two of the following were included in the Supplement:potassium benzoate, β-cyclodextrin, or γ-cyclodextrin. In some cases,three of the following were included in the Supplement: potassiumbenzoate, β-cyclodextrin, or γ-cyclodextrin.

Once each of the Mixtures were formed, the Mixtures were all combined inthe order shown in Table 5 to form about 2 to 3 gallons of theSupplement.

Example 3: Cancer Patient A and Patient B with GI Problems

Patient A (a child) was diagnosed with cancer and began taking theSupplement as a drink, along with chemo therapy and a healthy diet. Sixmonths after beginning this product and his treatments his doctors wereastonished. His healing and recovery are like nothing they have seenbefore.

A 37-year old relative of Patient A, Patient B, who had been strugglingwith gastrointestinal (GI) problems for years decided to try theSupplement product. Before taking the Supplement, Patient B sufferedfrom constipation that had become so bad that Patient B was hospitalizedmonths ago. Patient B had her gallbladder removed just over 3 month ago,and was feeling well until about the 3rd week after surgery when PatientB had trouble whenever she had a meal. Patient B could not eat half ameal without feeling bloated, gassy, nauseous, tired, and with lowenergy. Doctors prescribed some ineffective laxatives and stoolsofteners. Patient B was literally bed ridden for days clue toconstipation and weakness, Patient B stopped eating meals and wasreduced to snacking. That is when Patient B began to take the Supplementdrink. The first day Patient B took 1 to 2 ounces and did not noticemany effects, but by the second day Patient B was having normal bowelmovements and feeling like she was a teen again! Patient B has beentaking the Supplement drink three times a day for weeks now and hercondition is 100% completely better.

Patient B reports that this Supplement brought her back to a normal lifeand she is feeling better than she has in years!

Example 4: Patient C and Family have More Energy

Patient C is a 45-year old woman who had been suffering from anemia andhad been having minimal sleep. She has children who are all under theage of 16. Patient C and her children have been taking the Supplementfor a while now.

Since the start of taking the Supplement drink the children have notbecome sick. The oldest children report that when they have skip takingthe Supplement drink for a day, they find it harder to focus at school,and feel tired.

Since taking the Supplement drink, Patient C has noticed that her ironlevels have stayed at normal levels and Patient C has more energy.Patient C and her children have not noticed any negative side effects.

Example 5: Patient D with Celiacs Disease

From the time Patient D was a toddler she had been diagnosed with arather aggressive case of Celiacs, which has led to a life of variousconditions and multiple hospitalizations due to a compromised immunesystem. Patient D has had two bouts of cancer twice and has had twooperations to remove tumors.

During her pregnancy in 2016-2017, Patient D had anemia. When Patient Dwas tested, her cell count indicated that the cancer had returned.Because of her pregnancy, Ultrasounds were performed showing that thebaby was developing a ureteropelvic junction (UPJ) and could possiblyhave kidney issues. Patient D did not want to perform a lot ofadditional testing or take drugs that might harm the baby.

Patient D started taking the Supplement drink a little after half waythrough her pregnancy and continued for more than a year afterwards.During her C-section the doctors were not able to visibly see any tumorsand drew blood for a full screening. Weeks after giving birth, Patient Dreceived multiple ultrasounds and all the tests came back negativeincluding the anemia. The Doctors could no longer find or detect any ofthe problems they had seen months prior and were stunned. A year later,all of the blood screenings Patient D received were still negative.

Patient D's child was born with hydronephrosis and torticollis. PatientD started giving her child a small amount of the Supplement drink daily.Within 9 months the child went from having drastically different sizeureters to being given a clean bill of health from Pediatric Urologist.

Patient D attributes the improved health that she and her child haveexperienced to this Supplement.

Example 6: Patient E has Lost Weight and has Improved Immune Responses

Patient E took the Supplement daily to see if it would promote astronger immune system, overall health, and potentially would promoteweight loss in terms of fat reduction.

Patient E began testing this supplement several months ago with severalfriends who also wanted to see what anecdotal evidence they could find.Patient E and several others all experienced very similar outcomes.

Patient E observed noticeable benefits the first day he took theSupplement. His hunger cravings were substantially lessened. Typically,Patient E could not go more than 3 hours without food. Patient E took 3shots a day that consisted of 25 ml per dose. After a couple daysPatient E started to feel higher energy levels and even seemed to have aclearer thought process. This product also seemed to regulate his GItrack in a positive way. Recently over the last 6 months Patient E hasjust been doing 1 shot a day for health maintenance purposes.

After about 30 days of using this supplement, Patient E began to losesome body fat. Patient E is a weight lifter so this was a welcome sightwhen looking in the mirror. Patient E dropped about 12 lbs over 3months. Patient E consumed plenty of protein to maintain muscle mass,and suspects that little higher protein consumption with the Supplementmay enhance its benefits.

Patient E observed another intriguing benefit—he rarely gets sickanymore. While everyone around me is getting the seasonal flu and colds,Patient E either does not get these diseases, or he gets a very mildversion of them. While everyone else is in bed sick, Patient E is stillgoing about his usual activities. Patient E reports that this never usedto be the case before he started taking the Supplement.

The other people who took this for several months all reported the samething.

All patents and publications referenced or mentioned herein areindicative of the levels of skill of those skilled in the art to whichthe invention pertains, and each such referenced patent or publicationis hereby specifically incorporated by reference to the same extent asif it had been incorporated by reference in its entirety individually orset forth herein in its entirety. Applicants reserve the right tophysically incorporate into this specification any and all materials andinformation from any such cited patents or publications.

The following statements are intended to describe and summarize variousaspects of the invention according to the foregoing description in thespecification.

Statements:

-   -   1. A composition comprising at least four of the following        components: an amino acid blend, one or more fulvic-humic acids,        one or more multi-minerals, glycerin, one or more        phosphatidylinositols, one or more sesquiterpene alkaloids, one        or more terpenes, one or more medium-chain triglycerides (MCTs),        coconut oil, one or more (e.g. powdered or shredded) whole        plants, one or more (e.g., powdered) plant seeds, one or more        (e.g. powdered or shredded) mushrooms, one or more (e.g.        powdered or shredded) seaweeds, one or more (e.g. powdered or        shredded) kelp, one or more (e.g. powdered or shredded)        flavoring agents.    -   2. The composition of statement 1, comprising at least five, or        at least of six, or at least seven, or at least eight, or at        least nine, or at least ten, or at least eleven, or at least        twelve of the following components: an amino acid blend, one or        more Fulvic-humic acids, one or more multi-minerals, glycerin,        one or more phosphatidylinositols, one or more sesquiterpene        alkaloids, one or more terpenes, one or more medium-chain        triglycerides (MCTs), coconut oil, one or more (e.g. powdered or        shredded) whole plants, one or more plant seeds, one or more        (e.g. powdered or shredded) mushrooms, one or more (e.g.        powdered or shredded) seaweeds, one or more (e.g. powdered or        shredded) kelp, one or more (e.g. powdered or shredded)        flavoring agents.    -   3. The composition of statement 1 or 2, wherein the amino acid        blend comprises at least five, or at least six, or at least        seven, or at least eight, or at least nine, or at least ten, or        at least eleven, or at least twelve, or at least thirteen, or at        least fourteen, or at least fifteen, or at least sixteen, or at        least seventeen, or at least eighteen of the following: alanine,        arginine, aspartic acid, cysteine, cystine, glutamic acid,        glycine, histidine, isoleucine, lysine, leucine, methionine,        phenylalanine, serine, proline, threonine, tryptophan, tyrosine,        and/or valine.    -   4. The composition of statement 1, 2, or 3, wherein a single        serving each component of the amino acid blend can separately        range from about 1 μg/Kg to about 15 mg/Kg, or from about 0.5        mg/Kg to about 14 mg/Kg, or from about 1 mg/Kg to about 13        mg/Kg, or any intervening range therein.    -   5. The composition of statement 1-3, or 4, wherein the        fulvic-humic acids comprise humic acids, fulvic acids, and        humin.    -   6. The composition of statement 1-4, or 5, wherein a single        serving of fulvic-humic acids ranges from about 1 mg/Kg to about        50 mg/Kg, or from about 5 mg/Kg to about 40 mg/Kg, or from about        10 mg/Kg to about 30 mg/Kg. In many cases humic/fulvic acid        content can be about 20 mg/Kg per serving, or any intervening        range therein.    -   7. The composition of statement 1-5, or 6, wherein a single        serving of fulvic-humic acids from Vital Earth (Fulvic Mineral        Complex Ionic Mineral Supplement) is about 0.5 to about 2 fluid        ounces.    -   8. The composition of statement 1-6, or 7, wherein the one or        more multi-minerals include one or more salts of antimony,        barium, beryllium, bismuth, boron, bromine, cadmium, calcium,        cerium, cesium, chloride, chromium, cobalt, copper, dysprosium,        erbium, europium, fluorine, gadolinium, gallium, germanium,        gold, hafnium, holmium, indium, iodine, iridium, iron,        lanthanum, lithium, lutetium, magnesium, manganese, molybdenum,        neodymium, nickel, niobium, osmium, palladium, phosphorous,        platinum, potassium, praseodymium, rhenium, rhodium, rubidium,        ruthenium, samarium, scandium, selenium, silicon, silver,        sodium, strontium, sulfur, tantalum, tellurium, terbium,        thulium, thorium, tin, titanium, tungsten, vanadium, ytterbium,        yttrium, zinc, zirconium, or any combination thereof.    -   9. The composition of statement 1-7, or 8, wherein the one or        more salts comprise cations or anions in combination with        corresponding gegenions.    -   10. The composition of statement 9, wherein salts of mineral        cations comprise halogen, sulfate, nitrate, and phosphate        anions.    -   11. The composition of statement 9, wherein salts of mineral        anions comprise oxygenated forms of transition metals and        non-metallic elements (Groups III-VII of the Periodic Chart),        alkaline and alkaline earth metal salts.    -   12. The composition of statement 1-10, or 11, wherein a single        serving of each of minerals ranges from about 0.01 μg/Kg to        about 100 mg/Kg, or from about 0.1 ng/Kg to about 50 mg/Kg, or        from about 1 μg/Kg to about 40 mg/Kg, or from about 5 μg/Kg to        about 30 mg/Kg, or from about 10 μg/Kg to about 30 mg/Kg, or        from about 1 μg/Kg to about 25 mg/Kg, or any intervening range        therein.    -   13. The composition of statement 1-11, or 12, wherein glycerin        is a vegetable glycerin.    -   14. The composition of statement 1-12, or 13, wherein a single        serving of glycerin is about 0.1 mg/Kg to about 10 mg/Kg, or        from about 10 mg/Kg to about 80 mg/Kg, or from about 20 mg/Kg to        about 60 mg/Kg. In many cases the glycerin content can be about        45 mg/Kg, or any intervening range therein.    -   15. The composition of statement 1-13, or 14, wherein        phosphatidylinositol comprises one or two phosphates, 1-6 fatty        acids, and 1-4 phosphoinositol sugars.    -   16. The composition of statement 1-14, or 15, wherein a single        serving of the phosphatidylinositol is about 0.1 mg/Kg to about        10 mg/Kg, or from about 0.2 mg/Kg to about 5 mg/Kg, or from        about 0.3 mg/Kg to about 2 mg/Kg, or any intervening range        therein.    -   17. The composition of statement 1-15, or 16, wherein the        terpenes or sesquiterpenes comprise at least one, or at least        two, or at least three, or at least four, or at least five, or        at least six, or at least seven, or at least eight, or at least        nine, or at least ten of the following: alpha-humulene,        alpha-phellandrene, alpha-pinene, alpha-terpinene,        alpha-terpinolene, beta-myrcene, beta-pinene, camphene,        cis-ocimene, delta-3 carene, limonene, or any combinations        thereof.    -   18. The composition of statement 1-16, or 17, wherein the        terpenes or sesquiterpenes comprise one or more sesquiterpene        alkaloid compound.    -   19. The composition of statement 1-17, or 18, wherein the        terpenes or sesquiterpenes comprise huperzine A, with the        following structure:

-   -   20. The composition of statement 1-18, or 19, wherein a single        serving of terpenes and/or sesquiterpenes is about 0.01 μg/Kg to        about 100 mg/Kg, about 0.05 μg/Kg to about 50 mg/Kg, or about        0.1 μg/Kg to about 40 mg/Kg, or any intervening range therein.    -   21. The composition of statement 1-19, or 20, wherein each of        the middle chain triglycerides (MCTs) comprise a glycerol        moiety, and C₆, C₈, C₁₀ and/or C₁₂ fatty acids.    -   22. The composition of statement 1-20, or 21, wherein about 0%        to 3% of the middle chain triglycerides comprise C₆ fatty acids.    -   23. The composition of statement 1-21, or 22, wherein about 50%        to 100% of the middle chain triglycerides comprise C₈ fatty        acids.    -   24. The composition of statement 1-22, or 23, wherein about 15%        to 60% of the middle chain triglycerides comprise C₁₀ fatty        acids.    -   25. The composition of statement 1-23, or 24, wherein about 0%        to 3% of the middle chain triglycerides comprise C₁₂ fatty        acids.    -   26. The composition of statement 1-24, or 25, wherein about        fatty acids in the middle chain triglycerides are C₈ and C₁₀        fatty acids in ratios of about from 1:3 to 3:1.    -   27. The composition of statement 1-25, or 26, wherein a single        serving of the middle chain triglycerides is about 0.01 mg/Kg to        about 500 mg/Kg, about 0.05 mg/Kg to about 300 mg/Kg, or about        0.1 mg/Kg to about 200 mg/Kg, or any intervening range therein.    -   28. The composition of statement 1-26, or 27, wherein the middle        chain triglycerides comprise caprylic acid.    -   29. The composition of statement 1-27, or 28, wherein the middle        chain triglycerides comprise caprylic acid and a single serving        of caprylic acid is about 1 mg/Kg to about 100 mg/Kg, or from        about 10 mg/Kg to about 80 mg/Kg, or from about 10 mg/Kg to        about 60 mg/Kg, or any intervening range therein.    -   30. The composition of statement 1-28, or 29, wherein the middle        chain triglycerides comprise caprylic acid and a single serving        of caprylic acid is about 1,000 to 3,000 milligrams per day.    -   31. The composition of statement 1-29, or 30, comprising coconut        oil wherein a single serving of coconut oil is about 10 mg/Kg to        about 100 mg/Kg, or from about 20 mg/Kg to about 80 mg/Kg, or        from about 25 mg/Kg to about 60 mg/Kg, or any intervening range        therein.    -   32. The composition of statement 1-30, or 31, wherein the one or        more (e.g. powdered or shredded) whole plants comprise        Astragalus, fenugreek, monk fruit, and combinations thereof.    -   33. The composition of statement 1-31, or 32, wherein the one or        more (e.g. powdered or shredded) whole plants comprises        Astragalus of species Astragalus membranaceus.    -   34. The composition of statement 1-32, or 33, wherein a single        serving is about 1 mg/Kg to about 70 mg/Kg, or from about 3        mg/Kg to about 60 mg/Kg, or from about 5 mg/Kg to about 55        mg/Kg, or any intervening range therein.    -   35. The composition of statement 1-33, or 34, wherein the one or        more (e.g. powdered or shredded) whole plants comprises        fenugreek of the family Fabaceae.    -   36. The composition of statement 1-34, or 35, wherein a single        serving of fenugreek is about 0.1 mg/Kg to about 70 mg/Kg, or        from about 0.5 mg/Kg to about 60 mg/Kg, or from about 1 mg/Kg to        about 55 mg/Kg, or any intervening range therein.    -   37. The composition of statement 1-35, or 36, wherein the one or        more (e.g. powdered or shredded) whole plants comprises monk        fruit of species Siraitia grosvenorii.    -   38. The composition of statement 1-36, or 37, wherein a single        serving of monk fruit is about 0.1 grams to 40 grams, or about        0.2 to 30 grams, or about 0.3 to 20 grams, or about 0.5 to 20        grams, or any intervening range therein.    -   39. The composition of statement 1-37, or 38, wherein the plant        seeds comprise black seeds, chia seeds, flax seeds, raw pepita        seeds, Goji berries, and combinations thereof.    -   40. The composition of statement 1-38, or 39, wherein the plant        seeds comprise black seeds of species Nigella sativa.    -   41. The composition of statement 1-39, or 40, wherein a single        serving of black seeds is about 0.001 grams to 40 grams, or        about 0.002 to 10 grams, or about 0.003 to 2 grams, or about        0.003 to 1 grams, or any intervening range therein.    -   42. The composition of statement 1-40, or 41, wherein the plant        seeds comprise chia seeds of species Salvia hispanica.    -   43. The composition of statement 1-41, or 42, wherein a single        serving of chia seeds is about 0.1 grams to 50 grams, or about 1        to 40 grams, or about 5 to 35 grams, or about 10 to 35 grams, or        about 15 to 25 grams, or any intervening range therein.    -   44. The composition of statement 1-42, or 43, wherein the plant        seeds comprise flax seeds of species Linum usitatissimum.    -   45. The composition of statement 1-43, or 44, wherein a single        serving of flaxseeds is about 1 grams to 100 grams, or about 3        to 75 grams, or about 5 to 60 grams, or about 10 to 50 grams, or        about 20 to 45 grams, or any intervening range therein.    -   46. The composition of statement 1-44, or 45, wherein the plant        seeds comprise raw pepita seeds.    -   47. The composition of statement 1-45, or 46, wherein a single        serving of pepita seeds is about 1 grams to 150 grams, or about        5 to 100 grams, or about 10 to 75 grams, or about 15 to 50        grams, or about 20 to 45 grams, or any intervening range        therein.    -   48. The composition of statement 1-46, or 47, wherein the plant        seeds comprise Goji berry or wolfberry is of species Lycium        barbarum or Lycium chinense.    -   49. The composition of statement 1-47, or 48, wherein a single        serving of Goji berry or wolfberry is about 50 to 1000 mg, or        about 75 to 500 mg, or about 5 to 125 grams, or about 10 to 100        grams, or about 20 to 90 grams, or about 30 to 75 grams, or any        intervening range therein.    -   50. The composition of statement 1-48, or 49, wherein the        mushrooms comprise Brazillian Blazei (Agaricus blazei),        Caterpillar Mushroom (Cordyceps sinensis), Agarikon (Fomitopsis        officinalis), Turkey Tail (Coriolus versicolor), Enoki        (Flammulina velutipes), reishi (Ganoderma lucidum), Artist Conk        (Ganoderma applanatum), Maitake (Grifola frondosa), Lion's Mane        (Hericium erinaceus), Chaga (Inonotus obliquus), Shiitake        (Lentinula edodes), Birch Polypore (Piptoporus betulinus),        Mesimakobu (Phellinus linteus), Zhu ling (Polyporus umbellatus),        Fuling (Poria cocos), or a combination thereof.    -   51. The composition of statement 1-49, or 50, wherein the        mushrooms comprise Brazillian Blazei (Agaricus blazei) and        wherein a single serving of Brazillian Blazei (Agaricus blazei)        is about 0.1 grams to 40 grams, or about 0.5 to 25 grams, or        about 1 to 15 grams, or about 1.5 to 10 grams, or about 1.5 to 7        grams, or any intervening range therein.    -   52. The composition of statement 1-50, or 51, wherein the        mushrooms comprise Caterpillar Mushroom (Cordyceps sinensis) and        wherein a single serving of Caterpillar Mushroom (Cordyceps        sinensis) about 0.01 grams to 20 grams, or about 0.05 to 15        grams, or about 0.1 to 10 grams, or about 0.5 to 5 grams, or        about 1 to 3 grams, or any intervening range therein.    -   53. The composition of statement 1-51, or 52, wherein the        mushrooms comprise Agarikon (Fomitopsis officinalis) and wherein        a single serving of Agarikon (Fomitopsis officinalis) is about        0.1-20 gm./day, or about 0.25-10 gm./day, or about 0.5-5        gm./day, or any intervening range therein    -   54. The composition of statement 1-52, or 53, wherein the        mushrooms comprise Turkey Tail (Coriolus versicolor) and wherein        a single serving of Turkey Tail (Coriolus versicolor) is about        0.01 grams to 20 grams, or about 0.5 to 15 grams, or about 1 to        12 grams, or about 3 to 10 grams, or about 5 to 10 grams, or any        intervening range therein.    -   55. The composition of statement 1-53, or 54, wherein the        mushrooms comprise Enoki (Flammulina velutipes) and wherein a        single serving of Enoki (Flammulina velutipes) is about 0.1        grams to 200 grams, or about 0.5 to 150 grams, or about 1 to 100        grams, or about 1 to 50 grams, or about 2 to 10 grams, or any        intervening range therein.    -   56. The composition of statement 1-54, or 55, wherein the        mushrooms comprise reishi (Ganoderma lucidum) and wherein a        single serving of reishi (Ganoderma lucidum) is about 0.5 to 100        grams, or about 1 to 50 grams, or about 2 to 20 grams, or about        3 to 10 grams, or any intervening range therein.    -   57. The composition of statement 1-55, or 56, wherein the        mushrooms comprise Artist Conk (Ganoderma applanatum) and        wherein a single serving of Artist Conk (Ganoderma applanatum)        is about 0.5 to 100 grams, or about 1 to 50 grams, or about 2 to        20 grams, or about 3 to 10 grams, or any intervening range        therein.    -   58. The composition of statement 1-56, or 57, wherein the        mushrooms comprise Maitake (Grifola frondosa) and wherein a        single serving of Maitake (Grifola frondosa) is about 0.01 grams        to 20 grams, or about 0.05 to 15 grams, or about 0.1 to 10        grams, or about 0.3 to 7 grams, or about 0.4 to 5 grams, or any        intervening range therein.    -   59. The composition of statement 1-57, or 58, wherein the        mushrooms comprise Lion's Mane (Hericium erinaceus) and wherein        a single serving of Lion's Mane (Hericium erinaceus) is about        0.01 grams to 20 grams, or about 0.05 to 15 grams, or about 0.1        to 10 grams, or about 0.3 to 7 grams, or about 0.4 to 5 grams,        or any intervening range therein.    -   60. The composition of statement 1-58, or 59, wherein the        mushrooms comprise Chaga (Inonotus obliquus) and wherein a        single serving of Chaga (Inonotus obliquus) is about 0.01 grams        to 20 grams, or about 0.05 to 15 grams, or about 0.1 to 10        grams, or about 0.3 to 7 grams, or about 0.3 to 5 grams, or any        intervening range therein.    -   61. The composition of statement 1-59, or 60, wherein the        mushrooms comprise Shiitake (Lentinula edodes) and wherein a        single serving of Shiitake (Lentinula edodes) is about 0.1 grams        to 30 grams, or about 0.5 to 20 grams, or about 1 to 15 grams,        or about 2 to 12 grams, or about 4 to 11 grams, or any        intervening range therein.    -   62. The composition of statement 1-60, or 61, wherein the        mushrooms comprise Birch Polypore (Piptoporus betulinus) and        wherein a single serving of Birch Polypore (Piptoporus        betulinus) is about 0.1 grams to 30 grams, or about 0.5 to 20        grams, or about 1 to 15 grams, or about 2 to 12 grams, or about        4 to 11 grams, or any intervening range therein.    -   63. The composition of statement 1-61, or 62, wherein the        mushrooms comprise Mesimakobu (Phellinus linteus) and wherein a        single serving of Mesimakobu (Phellinus linteus) is about 1        grams to 100 grams, or about 2 to 75 grams, or about 2 to 50        grams, or about 2 to 25 grams, or about 3 to 15 grams, or any        intervening range therein.    -   64. The composition of statement 1-62, or 63, wherein the        mushrooms comprise Zhu ling (Polyporus umbellatus) and wherein a        single serving of Zhu ling (Polyporus umbellatus) is about 0.01        grams to 20 grams, or about 0.05 to 15 grams, or about 0.1 to 10        grams, or about 0.3 to 7 grams, or about 0.3 to 5 grams, or any        intervening range therein.    -   65. The composition of statement 1-63, or 64, wherein the        mushrooms comprise Fuling (Poria cocos) and wherein a single        serving of Fuling (Poria cocos) is about 0.5 to 100 grams, or        about 1 to 50 grams, or about 2 to 25 grams, or about 5 to 20        grams, or any intervening range therein.    -   66. The composition of statement 1-64, or 65, wherein a single        serving of each of the mushrooms is about 10 to 500 mg, or about        20 to 400 mg, or about 30 to 300 mg, or about 50 to 200 mg.    -   67. The composition of statement 1-65, or 66, wherein the one or        more (e.g. powdered or shredded) seaweeds or kelp comprise        Spirulina powder, blue green algae, Chlorella, and combinations        thereof.    -   68. The composition of statement 1-66, or 67, wherein a single        daily serving of each seaweed or kelp is about 0.5 to 100 grams,        or about 1 to 50 grams, or about 2 to 25 grams, or about 5 to 20        grams, or any intervening range therein.    -   69. The composition of statement 1-67, or 68, wherein a single        serving of each seaweed or kelp is about 1 to 200 mg, or about        10 to 150 mg, or about 30 to 100 mg, or any intervening range        therein.    -   70. The composition of statement 1-68, or 69, comprising        flavorings that are natural or artificial.    -   71. The composition of statement 1-69, or 70, comprising        flavorings selected from strawberry, plum, banana, blueberry,        cherry, cinnamon, coconut, coffee, chocolate (e.g., dark        chocolate), raspberry, grape, green apple, lemon, mango,        menthol, mint, mojito, orange, peach, pear, pineapple,        pomegranate, root beer, tobacco, vanilla, watermelon, or        combinations thereof.    -   72. The composition of statement 1-70, or 71, comprising at        least one freshness preservation agent.    -   73. The composition of statement 1-71, or 72, comprising at        least one freshness preservation agent selected from potassium        benzoate, β-cyclodextrin, γ-cyclodextrin, or a combination        thereof.    -   74. The composition of statement 1-72, or 73, comprising at        least one freshness preservation agent at about 0.01% by weight        to about 5% by weight of the supplement food weight.    -   75. A method comprising administering the composition of        statement 1-73 or 74 to an animal.    -   76. The method of statement 75, wherein the animal is a human, a        domesticated animal, or a zoo animal.    -   77. The method of statement 75 or 76, wherein the composition        reduces the incidence or severity of disease compared to an        animal of the same species that does not receive the        composition.    -   78. The method of statement 75, 76, or 77, comprising        administering the composition to the animal for 1 week to 52        weeks, for 2 weeks to 104 weeks, or for indefinitely.    -   79. A composition comprising:        -   amino acid powder: alanine, arginine, aspartic acid,            cysteine or cystine, glutamic acid, glycine, histidine,            isoleucine, lysine, leucine, methionine, phenylalanine,            serine, proline, threonine, tryptophan, tyrosine, and            valine;        -   fulvic-humic acids;        -   minerals;        -   glycerin;        -   phosphatidylinositol;        -   (±)-huperzine A;        -   caprylic Acid (octanoic acid);        -   medium chain triglycerides;        -   coconut oil;        -   Astragalus plant matter, fenugreek plant matter, monk fruit            plant matter;        -   liquid or powdered black seeds, liquid or powdered chia            seeds, liquid or powdered flax seeds, liquid or powdered raw            pepita seeds, liquid or powdered goji berries;        -   terpene powder: alpha-humulene, alpha-phellandrene,            alpha-pinene, alpha-terpinene, alpha-terpinolene,            beta-myrcene, beta-pinene, camphene, cis-ocimene, delta-3            carene, limonene;        -   liquid or powdered mushroom mixture: Brazillian Blazei            (Agaricus blazei), Caterpillar Mushroom (Cordyceps            sinensis), Agarikon (Fomitopsis officinalis), Turkey Tail            (Coriolus versicolor), Enoki (Flammulina velutipes), reishi            (Ganoderma lucidum), Artist Conk (Ganoderma applanatum),            Maitake (Grifola frondosa), Lion's Mane (Hericium            erinaceus), Chaga (Inonotus obliquus), Shiitake (Lentinula            edodes), Birch Polypore (Piptoporus betulinus), Mesimakobu            (Phellinus linteus), Zhu ling (Polyporus umbellatus), Fuling            (Poria cocos);            -   liquid or powder seaweed and/or kelp: Spirulina, blue                green algae, Chlorella; and            -   potassium benzoate.    -   80. The composition of claim 78, further comprising one or more        of the following flavoring agents: strawberry, plum, banana,        blueberry, cherry, cinnamon, coconut, coffee, chocolate (e.g.,        dark chocolate), raspberry, grape, green apple, lemon, mango,        menthol, mint, mojito, orange, peach, pear, pineapple,        pomegranate, root beer, tobacco, vanilla, watermelon.

The specific methods and compositions described herein arerepresentative of preferred embodiments and are exemplary and notintended as limitations on the scope of the invention. Other objects,aspects, and embodiments will occur to those skilled in the art uponconsideration of this specification, and are encompassed within thespirit of the invention as defined by the scope of the claims. It willbe readily apparent to one skilled in the art that varying substitutionsand modifications may be made to the invention disclosed herein withoutdeparting from the scope and spirit of the invention. The inventionillustratively described herein suitably may be practiced in the absenceof any element or elements, or limitation or limitations, which is notspecifically disclosed herein as essential. The methods and processesillustratively described herein suitably may be practiced in differingorders of steps, and the methods and processes are not necessarilyrestricted to the orders of steps indicated herein or in the claims.

As used herein and in the appended claims, the singular forms “a,” “an,”and “the” include plural reference unless the context clearly dictatesotherwise. Thus, for example, a reference to “a compound,” “a cell,” “anutrient” or “an amino acid” includes a plurality of such compounds,cells, nutrients or amino acids (for example, a solution of cells,nutrients, or amino acids, a suspension of cells, or a series ofcompound, nutrient, or amino acid preparations), and so forth. Under nocircumstances may the patent be interpreted to be limited to thespecific examples or embodiments or methods specifically disclosedherein. Under no circumstances may the patent be interpreted to belimited by any statement made by any Examiner or any other official oremployee of the Patent and Trademark Office unless such statement isspecifically and without qualification or reservation expressly adoptedin a responsive writing by Applicants.

The terms and expressions that have been employed are used as terms ofdescription and not of limitation, and there is no intent in the use ofsuch terms and expressions to exclude any equivalent of the featuresshown and described or portions thereof, but it is recognized thatvarious modifications are possible within the scope of the invention asclaimed. Thus, it will be understood that although the present inventionhas been specifically disclosed by preferred embodiments and optionalfeatures, modification and variation of the concepts herein disclosedmay be resorted to by those skilled in the art, and that suchmodifications and variations are within the scope of this invention asdefined by the appended claims and statements of the invention.

1. A composition comprising at least four of the following components:an amino acid blend, an fulvic-humic acid, a mineral, glycerin, aphosphatidylinositol, an sesquiterpene alkaloid, a terpene, amedium-chain triglyceride, coconut oil, a powdered or shredded wholeplant, a plant seed, a powdered or shredded mushroom, seaweed, kelp, ora flavoring agent.
 2. The composition of claim 1, wherein the amino acidblend comprises at least five of the following: alanine, arginine,aspartic acid, cysteine, cystine, glutamic acid, histidine, isoleucine,lysine, leucine, methionine, phenylalanine, serine, proline, threonine,tyrosine, and/or valine.
 3. The composition of claim 1, wherein thefulvic-humic acid comprises humic acids, fulvic acids, humin, or amixture thereof.
 4. The composition of claim 1, wherein the mineral isone or more salts of antimony, barium, beryllium, bismuth, boron,bromine, cadmium, calcium, cerium, cesium, chloride, chromium, cobalt,copper, dysprosium, erbium, europium, fluorine, gadolinium, gallium,germanium, gold, hafnium, holmium, indium, iodine, iridium, iron,lanthanum, lithium, lutetium, magnesium, manganese, molybdenum,neodymium, nickel, niobium, osmium, palladium, phosphorous, platinum,potassium, praseodymium, rhenium, rhodium, rubidium, ruthenium,samarium, scandium, selenium, silicon, silver, sodium, strontium,sulfur, tantalum, tellurium, terbium, thulium, thorium, tin, titanium,tungsten, vanadium, ytterbium, yttrium, zinc, zirconium, or anycombination thereof.
 5. The composition of claim 1, wherein glycerin isa vegetable glycerin.
 6. The composition of claim 1, wherein thephosphatidylinositol comprises one or two phosphates, 1-6 fatty acids,and 1-4 phosphoinositol sugars.
 7. The composition of claim 1, whereinthe terpene or sesquiterpene comprises at least one of the following:alpha-humulene, alpha-phellandrene, alpha-pinene, alpha-terpinene,alpha-terpinolene, beta-myrcene, beta-pinene, camphene, cis-ocimene,delta-3 carene, limonene, or any combinations thereof.
 8. Thecomposition of claim 1, wherein the terpene or sesquiterpene comprisesone or more sesquiterpene alkaloid compound.
 9. The composition of claim1, wherein the terpene or sesquiterpene comprises huperzine A, with thefollowing structure:


10. The composition of claim 1, wherein each of the middle chaintriglyceride comprises a glycerol moiety, and one or more C₆, C₈, C₁₀ orC₁₂ fatty acids.
 11. The composition of claim 1, wherein the middlechain triglycerides comprises caprylic acid.
 12. The composition ofclaim 1, wherein the powdered or shredded whole plant comprises powderedor shredded Astragalus, fenugreek, monk fruit, or any combinationthereof.
 13. The composition of claim 1, wherein the plant seedcomprises black seeds, chia seeds, flax seeds, raw pepita seeds, Gojiberries, wolfberries, or any combination thereof.
 14. The composition ofclaim 1, wherein the mushroom comprises Brazillian Blazei (Agaricusblazei), Caterpillar Mushroom (Cordyceps sinensis), Agarikon (Fomitopsisofficinalis), Turkey Tail (Coriolus versicolor), Enoki (Flammulinavelutipes), reishi (Ganoderma lucidum), Artist Conk (Ganodermaapplanatum), Maitake (Grifola frondosa), Lion's Mane (Hericiumerinaceus), Chaga (Inonotus obliquus), Shiitake (Lentinula edodes),Birch Polypore (Piptoporus betulinus), Mesimakobu (Phellinus linteus),Zhu ling (Polyporus umbellatus), Fuling (Poria cocos), or anycombination thereof.
 15. The composition of claim 1, wherein theseaweeds or kelp comprises Spirulina powder, blue green algae,Chlorella, or any combination thereof.
 16. The composition of claim 1,comprising flavorings that are natural flavorings.
 17. The compositionof claim 1, comprising at least one freshness preservation agent. 18.The composition of claim 1, comprising at least one freshnesspreservation agent selected from potassium benzoate, β-cyclodextrin,γ-cyclodextrin, or a combination thereof.
 19. The composition of claim1, comprising: amino acid powder: alanine, arginine, aspartic acid,cysteine or cystine, glutamic acid, histidine, isoleucine, lysine,leucine, methionine, phenylalanine, serine, proline, threonine,tyrosine, and valine; fulvic-humic acids; minerals, glycerin; caprylicAcid (octanoic acid); medium chain triglycerides; coconut oil; fenugreekplant matter, monk fruit plant matter; liquid or powdered black seeds,liquid or powdered flax seeds, liquid or powdered raw pepita seeds;terpene powder: alpha-humulene, alpha-phellandrene, alpha-pinene,alpha-terpinolene, beta-myrcene, beta-pinene; liquid or powderedmushroom mixture: Brazillian Blazei (Agaricus blazei), CaterpillarMushroom (Cordyceps sinensis), Agarikon (Fomitopsis officinalis), TurkeyTail (Coriolus versicolor), Enoki (Flammulina velutipes), reishi(Ganoderma lucidum), Artist Conk (Ganoderma applanatum), Maitake(Grifola frondosa), Lion's Mane (Hericium erinaceus), Chaga (Inonotusobliquus), Shiitake (Lentinula edodes), Birch Polypore (Piptoporusbetulinus), Mesimakobu (Phellinus linteus), Zhu ling (Polyporusumbellatus), Fuling (Poria cocos); liquid or powder seaweed and/or kelp:blue green algae; potassium benzoate
 20. The composition of claim 1comprising: mg per mg per mg per Kg 70 Kg 100 Kg Body Weight Body WeightBody Weight Component (1 Serving) (1 Serving) (1 Serving) Amino AcidsAlanine 5.8 406 588 Arginine 8.18 572.6 818 Aspartic Acid 1.092 76.441092 Cystine 2.88 201.6 288 Glutamic Acid 2.065 144.55 206.5 Glycine3.78 264.6 378 Histidine 2.7 189 270 Isoleucine 7 490 700 Lysine 8 614854 Leucine 10.91 763.7 1091 Methionine 2.76 193.2 276 Phenylalanine11.2 784 1120 Serine 11.2 784 1120 Proline 7.32 512.4 732 Threonine 5.7399 570 Tryptophan 1.87 130.9 187 Tyrosine 4.92 344.4 492 Valine 7.22505.4 722 Fulvic-humic acids 20 1400 2000 Multi-minerals 20 25 30β-Alanine 8 560 800 2,3-Diaminopropionic acid 0.05 3.5 5α-Aminoisobutyric acid 0.06 4.2 6 N-Methylglycine 0.06 4.2 6 (sarcosine)Ornithine 0.06 4.2 6 Citrulline 10 700 1000 t-Butylalanine 1 70 100t-Butylglycine 1 70 100 N-methylisoleucine 0.1 7 10 Phenylglycine 0.010.7 1 Cyclohexylalanine 0.035 2.45 3.5 Norleucine 0.25 10.5 15Naphthylalanine 0.1 7 10 Pyridylalanine 0.1 7 10 3-Benzothienyl alanine0.06 4.2 6 4-Chlorophenylalanine 0.25 17.5 25 2-Fluorophenylalanine 0.1510.5 15 3-Fluorophenylalanine 0.15 10.5 15 4-Fluorophenylalanine 0.1510.5 15 Penicillamine 3.75 262.5 375 1,2,3,4-Tetrahydro- 0.25 17.5 25isoquinoline-3-carboxylic acid E-2-thienylalanine 0.06 4.2 6 Methioninesulfoxide 4.7 μg 329 μg 470 μg Homoarginine 1.28 89.6 125 N-acetyllysine 6 420 600 2,4-Diamino butyric acid 0.01 0.7 1D-Aminophenylalanine 1 70 100 N-methylvaline 0.07 4.9 7 Homocysteine 170 100 Homoserine 0.3 21 30 Amino hexanoic acid 0.01 0.7 1 Amino valericacid 1.28 89.6 128 2,3-Diaminobutyric acid 0.01 0.7 1Phosphatidylinositol Phosphatidylinositol 0.6 42 60 Coconut ExtractionsCaprylic Acid 15 1050 1500 MCT 25 1750 2500 Coconut Oil 40 2800 4000Glycerin Glycerin 45 3150 4500 Terpenes/Sesquiterpene alkaloidsAlpha-Humulene 2.5 175 250 Alpha-Phellandrene 10 700 1000 Alpha-pinene4.5 315 450 Alpha-Terpinene 2.5 175 250 Alpha-Terpinolene 26 1820 2600Beta-Myrcene 0.7 49 70 Beta-pinene 5 350 500 Camphene 0.6 42 60Cis-Ocimene 2 140 200 Delta-3 Carene 1.1 77 110 Limonene 30 2100 3000Sabinene 2.5 175 250 Trans-Caryophyllene 1.4 98 140 Trans-Ocimene 1.1 77110 Y-Terpinene 1.5 105 150 1.8-Cineole 1.8 126 180 Perillyl alcohol 170 100 Flax seeds, Raw pepita Cold Pressed Plant/Seed Oil seeds, Chiaseeds Omega-6 linoleic acid (LA) 7 490 700 Omega-3 2.5 175 250alpha-linolenic acid (ALA) Omega-9 2 140 200 Omega-6 0.5 35 500 gammalinolenic acid (GLA) Omega-3 stearidonic acid 0.25 175 250 (SDA) BlackSeeds Black seeds 4 280 400 Goji berries Goji berries 2 140 200 Seaweedand/or kelp Seaweed and/or kelp 1 70 100 Fenugreek 95% + Fenugreekextract 48 3360 4800 Monk Fruit 95% + monk fruit extract 5 350 100Artemisia ludoviciana 95% + Artemisia 5 350 500 ludoviciana extractMushroom Extracts Brazillian Blazei (Agaricus 2 70-140 100-200 blazei)Caterpillar Mushroom 2 70-140 100-200 (Cordyceps sinensis, renamedOphiocordyceps sinensis) Enoki (Flammulina 2 70-140 100-200 velutipes)Agarikon (Fomitopsis 2 70-140 100-200 officinalis, also known asLaricifomes officinalis) Turkey Tail (Coriolus 2 70-140 100-200versicolor, also known as Trametes versicolor) Shitake 2 70-140 100-200Red Reishi 4 140-280  200-400 Fuling (Poria cocos) 2 70-140 100-200 Zhuling (Polyporus 2 70-140 100-200 umbellatus) Mesimakobu (Phellinus 270-140 100-200 linteus) Birch polypore (Piptoporus 2 70-140 100-200betulinus) Inonotus obliquus 2 70-140 100-200 Hericium erinaceus 270-140 100-200 Maitake (Grifola frondosa) 4 140-280  200-400 Artist Conk(Ganoderma 2 70-140 100-200 applanatum) Freshness preservationcompound(s) Potassium benzoate 0.02 1.4 2 β-cyclodextrin 0.02 1.4 2γ-cyclodextrin 0.02 1.4 2


21. A method comprising administering the composition of claim 1 to ananimal.
 22. The method of claim 21, comprising administering 1 to 5servings of the composition to an animal per day.
 23. The method ofclaim 21, wherein the composition reduces the incidence or severity ofdisease compared to an animal of the same species that does not receivethe composition.
 24. The composition of claim 1, comprising: amino acidblend comprising: alanine, arginine, aspartic acid, cysteine or cystine,glutamic acid, histidine, isoleucine, lysine, leucine, methionine,phenylalanine, serine, proline, threonine, tyrosine, and valine;fulvic-humic acids; minerals; glycerin; medium chain triglycerides;fenugreek, monk fruit; liquid or powdered black seeds, liquid orpowdered raw pepita seeds; terpenes alpha-humulene, alpha-phellandrene,alpha-pinene, alpha-terpinolene, beta-myrcene, beta-pinene; liquid orpowdered mushroom mixture: Brazillian Blazei (Agaricus blazei),Caterpillar Mushroom (Cordyceps sinensis), Agarikon (Fomitopsisofficinalis), Turkey Tail (Coriolus versicolor), Enoki (Flammulinavelutipes), reishi (Ganoderma lucidum), Artist Conk (Ganodermaapplanatum), Maitake (Grifola frondosa), Lion's Mane (Hericiumerinaceus), Chaga (Inonotus obliquus), Shiitake (Lentinula edodes),Birch Polypore (Piptoporus betulinus), Mesimakobu (Phellinus linteus),Zhu ling (Polyporus umbellatus), Fuling (Poria cocos); liquid or powderblue green algae; and potassium benzoate.